Linked Life Data

7783006

Source:http://linkedlifedata.com/resource/pubmed/id/7783006

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-7-19
pubmed:abstractText
The aim of the present investigation was to analyse the fibroblast phenotype in the main groups of odontogenic cysts. We have examined the muscle differentiation markers alpha-smooth muscle actin (ASMA) and desmin and the presence of vimentin using immunocytochemistry. Fibroblasts of other cyst types, hyperplastic fibrous lesions, and from several normal sites were used as controls. All fibroblasts stained for vimentin, but a variable proportion of cyst wall fibroblasts were also positive for the antibody to ASMA. Their distribution was not random and two positive zones could be distinguished, an inner subepithelial layer and an outer region adjacent to the bone-facing surface. This staining pattern was observed for all the types of odontogenic cysts studied, although the subepithelial staining was more frequent in the presence of an inflammatory infiltrate. The contractile nature of these cells was supported by their ultrastructural appearance. Some non-odontogenic cysts showed subepithelial fibroblasts strongly labelled with ASMA; in the control tissues ASMA was negative except for pericytes and some groups of cells in supracrestal gingiva. These results demonstrate a distinct cell population with a myofibroblast phenotype in the odontogenic cyst wall and with a distribution which may enable them to contribute to wall elasticity constraining cyst expansion. Their presence in all types of odontogenic cyst studied would suggest that myofibroblast formation is independent of the pattern of cyst growth.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0904-2512
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
170-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Immunohistochemical characterisation of odontogenic cysts with mesenchymal and myofilament markers.
pubmed:affiliation
Department of Oral Medicine & Pathology, UMDS Guy's Hospital, London, England.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't