Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-7-14
pubmed:abstractText
Halofuginone was evaluated for its activity against experimentally induced infection due to Cryptosporidium parvum in rats rendered immunosuppressed with dexamethasone. The drug's activity was dose-related and both prophylaxis and therapy reduced the rate and severity of infection in the small intestine and caecum. Prophylactic treatment reduced infection of the common bile duct, but therapeutic administration did not and neither form of treatment reduced the infection rate in the colon. Intestinal infection recurred at a level comparable to that of untreated controls when treatment was discontinued. Treatment with halofuginone may reduce the severity of acute cryptosporidiosis, but is less efficacious for chronic cryptosporidiosis involving the colon and extraintestinal tissues, a manifestation increasingly seen in the immunocompromised host.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0305-7453
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
391-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:7782255-Animals, pubmed-meshheading:7782255-Colonic Diseases, pubmed-meshheading:7782255-Common Bile Duct, pubmed-meshheading:7782255-Cryptosporidiosis, pubmed-meshheading:7782255-Cryptosporidium parvum, pubmed-meshheading:7782255-Dexamethasone, pubmed-meshheading:7782255-Dose-Response Relationship, Drug, pubmed-meshheading:7782255-Drug Evaluation, Preclinical, pubmed-meshheading:7782255-Feces, pubmed-meshheading:7782255-Female, pubmed-meshheading:7782255-Immunosuppression, pubmed-meshheading:7782255-Intestine, Large, pubmed-meshheading:7782255-Intestine, Small, pubmed-meshheading:7782255-Parasite Egg Count, pubmed-meshheading:7782255-Piperidines, pubmed-meshheading:7782255-Quinazolines, pubmed-meshheading:7782255-Quinazolinones, pubmed-meshheading:7782255-Rats, pubmed-meshheading:7782255-Rats, Sprague-Dawley, pubmed-meshheading:7782255-Treatment Outcome
pubmed:year
1995
pubmed:articleTitle
The activity of halofuginone in immunosuppressed rats infected with Cryptosporidium parvum.
pubmed:affiliation
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't