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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1995-7-18
|
| pubmed:abstractText |
Post-systolic shortening is a wall motion abnormality defined as shortening of cardiac muscle after the end of ejection and usually regarded as a manifestation of ischaemia. This study was designed to determine whether changes in preload may alter the magnitude of ischaemia-induced post-systolic shortening. Eleven beagles were anaesthetized (halothane 0.8%) and instrumented for measurement of pressures, flows and dimensions in the apical subendocardium supplied by the left anterior descending coronary artery. Myocardial ischaemia was obtained by tightening a micrometer-controlled snare around the left anterior descending coronary artery. Post-systolic shortening, calculated as end-systolic length minus minimum length divided by end-systolic length, was measured at different levels of preload. Increasing the preload from 4 to 17 mmHg caused a significant reduction in post-systolic shortening (8.9% vs. 12.9%, P < 0.05, Student's paired t-test); post-systolic shortening was negatively correlated with coronary perfusion pressure (r = 0.35, P < 0.01) and positively correlated with systolic bulging. This study demonstrates that the amount of post-systolic shortening depends on the volume status, which therefore has to be taken into account in interpreting regional wall motion abnormalities, such as those detected by echocardiography.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0265-0215
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
127-33
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7781631-Animals,
pubmed-meshheading:7781631-Dogs,
pubmed-meshheading:7781631-Female,
pubmed-meshheading:7781631-Male,
pubmed-meshheading:7781631-Myocardial Contraction,
pubmed-meshheading:7781631-Myocardial Ischemia,
pubmed-meshheading:7781631-Systole,
pubmed-meshheading:7781631-Ventricular Function, Left,
pubmed-meshheading:7781631-Ventricular Pressure
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
The influence of preload on post-systolic shortening in ischaemic myocardium.
|
| pubmed:affiliation |
Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|