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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1995-7-14
|
| pubmed:abstractText |
Endogenous nitric oxide (EDRF) plays an important role in the regulation of systemic and renal blood pressure by an alteration of vascular tone. To assess the effect of L-arginine (160 mumol/min i.v. for 3 hours), the precursor of EDRF, on blood pressure, protein-excretion and renal function (GFR = glomerular filtration rate, RPF = renal plasma flow) we performed a prospective, double blind, placebo controlled study. 18 patients with chronic glomerulonephritis (51.3 +/- 11.5 years), renal insufficiency (GFR < 65 ml/min) and hypertension were investigated for changes in GFR and RPF by continuous inulin- and PAH-clearances and for changes in permselectivity by determination of protein-excretion. L-arginine infusion results in a reduction of proteinuria (p < 0.05, t-test). There is no significant effect on renal hemodynamics and mean arterial pressure (MAP). Comparing the excretion of the endogenous proteins, only albuminuria is decreased significantly (p < 0.01), whereas IgG-excretion is reduced slightly (p < 0.05). This can be considered as an indicator of a special influence on the mesangial cells or the basement membrane of the glomerulum itself by EDRF. In conclusion L-arginine reduces protein-excretion without significant alterations in renal hemodynamics and so might prevent a decline in renal failure.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0301-0430
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
43 Suppl 1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S42-6
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:7781205-Adult,
pubmed-meshheading:7781205-Albuminuria,
pubmed-meshheading:7781205-Arginine,
pubmed-meshheading:7781205-Blood Pressure,
pubmed-meshheading:7781205-Double-Blind Method,
pubmed-meshheading:7781205-Female,
pubmed-meshheading:7781205-Glomerular Filtration Rate,
pubmed-meshheading:7781205-Glomerulonephritis,
pubmed-meshheading:7781205-Humans,
pubmed-meshheading:7781205-Hypertension,
pubmed-meshheading:7781205-Immunoglobulin G,
pubmed-meshheading:7781205-Male,
pubmed-meshheading:7781205-Middle Aged,
pubmed-meshheading:7781205-Nitric Oxide,
pubmed-meshheading:7781205-Prospective Studies,
pubmed-meshheading:7781205-Proteinuria,
pubmed-meshheading:7781205-Renal Circulation,
pubmed-meshheading:7781205-Renal Insufficiency
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Does L-arginine alter proteinuria and renal hemodynamics in patients with chronic glomerulonephritis and hypertension?
|
| pubmed:affiliation |
Section of Nephrology and Hypertension, University of Tübingen, Germany.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|