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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1995-7-14
|
| pubmed:abstractText |
A rapid synthesis of the chlorofluorocarbon replacement compound 1,1,1,2-tetrafluoroethane (HFA-134a) was identified and utilized to prepare 99+% radiochemically pure [18F]HFA-134a in 20-35% radiochemical yield. Four rats were then exposed to no-carrier-added (NCA) [18F]HFA-134a, and monitored via coincidence detection. Following withdrawal of the test atmosphere of [18F]HFA-134a, the mean half-life of [18F]HFA-134a in four rats was determined to be 7.8 +/- 1.5 min following a 10 s exposure and 8.1 +/- 1.7 minutes following a 10 min exposure.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0969-8043
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
46
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
241-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7780376-Animals,
pubmed-meshheading:7780376-Fluorine Radioisotopes,
pubmed-meshheading:7780376-Half-Life,
pubmed-meshheading:7780376-Hydrocarbons, Fluorinated,
pubmed-meshheading:7780376-Male,
pubmed-meshheading:7780376-Rats,
pubmed-meshheading:7780376-Rats, Sprague-Dawley,
pubmed-meshheading:7780376-Tissue Distribution
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Synthesis and in vivo disposition studies of 18F-labeled HFA-134a.
|
| pubmed:affiliation |
Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky, Lexington 40536-0082, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|