Linked Life Data

7780282

Source:http://linkedlifedata.com/resource/pubmed/id/7780282

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-7-19
pubmed:abstractText
Color Doppler imaging has demonstrated orbital hemodynamic changes in diseases such as central vein occlusion, the ocular ischemic syndrome and diabetic retinopathy. Reports of pharmacologically induced changes are, however, rare and inconsistent. In order to verify the sensitivity of color Doppler imaging to demonstrate pharmacologically induced changes in orbital hemodynamics, nitroglycerin and nifedipine served as vasoactive agents with a clear pharmacological spectrum. Twelve healthy volunteers were examined before and after drug application. After the administration of 0.8 mg nitroglycerin, the end diastolic bloodflow velocity was increased in the central retinal artery (before: Vdiastolic 2.2 +/- 1.0 cm/s, after: Vdiastolic 3.1 +/- 1.1 cm/s) as well as the ophthalmic artery (before: Vdiastolic 5.8 +/- 1.7 cm/s, after: Vdiastolic 7.4 +/- 1.8 cm/s). The resistance index of orbital blood flow decreased in all three vessels. After sublingual administration of 10 mg nifedipine, peak systolic blood flow velocity was slightly higher in the ciliary arteries and in the ophthalmic artery (before: Vsystolic 34.7 +/- 4.6 cm/s, after: Vsystolic 37.8 +/- 3.6 cm/s). Blood-flow velocity in the central retinal vein was elevated as well (before: Vmax 3.81 +/- 0.66 cm/s, after: Vmax 4.66 +/- 0.83 cm/s). Those slightly divergent results may be due to the different pharmacological spectrum of the two drugs investigated While nitroglycerin leads to dilatation of venous vessels, nifedipine acts primarily on small arteries. As nifedipine and other calcium channel blockers have been tested in patients with low-tension glaucoma, future color Doppler studies of such a population seem to be promising.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0941-293X
pubmed:author
pubmed:issnType
Print
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
206-11
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
[Changes in orbital hemodynamics caused by nitroglycerin and nifedipine. A study using color duplex ultrasound].
pubmed:affiliation
Universitäts-Augenklinik Mainz.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, English Abstract, Controlled Clinical Trial