Linked Life Data

7779680

Source:http://linkedlifedata.com/resource/pubmed/id/7779680

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-7-14
pubmed:abstractText
In Drosophila about 27 developmental genes have been identified which suppress tumorous growth and about as many genes are known to suppress overgrowth. Recessive lethal mutations in tumor suppressor genes block in one step the differentiation of specific target cells, leaving unaffected their capacity to divide in an autonomous, malignant and lethal fashion. The structural analysis of eight tumor suppressor genes predicts putative functions in differentiation events, such as cell-cell communication, protein transport and protein synthesis, signal transduction, sex determination splicing and cytokinesis. Their predicted products function as effectors of the differentiated state being vital components of cell junctions, the cytoskeleton, the protein synthetic apparatus, the splicing machinery and signal transduction. In contrast to the tumor suppressor genes, which are instrumental in the establishment and maintenance of the differentiated state, overgrowth suppressor genes seem to control cell-specific division rates while leaving unaffected the capacity of the cells to differentiate. The Drosophila tumor suppressor and overgrowth suppressor genes show clearly the mutual exclusion of the genetic programs controlling cell division and cell differentiation. Some of the genes exhibit homologies to mammalian genes. Their functional homology, however, is still an open question.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0214-6282
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
565-90
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Tumor suppressor and overgrowth suppressor genes of Drosophila melanogaster: developmental aspects.
pubmed:affiliation
Institut für Genetik, Johannes Gutenberg Universität, Mainz, Germany.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't