Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-7-7
pubmed:abstractText
The purpose of the present study was to investigate the effects of the flavonoid delphinidin chloride (CAS 528-53-0, IdB 1056) on diabetic microangiopathy. Hamsters were injected with alloxan and cheek pouch microcirculation was observed by a fluorescent microscopy technique 90 days from alloxan. The increase in permeability, the number of adhering leukocytes to venular vessel wall and vasodilatory responses to acetylcholine (Ach) and sodium nitroprusside (SNP) were measured. In diabetic group microvascular permeability and the number of sticking leukocytes to the venular endothelium were increased. Vasoconstriction by Ach was observed while the vasodilation by SNP was significantly attenuated in diabetic animals. These results are consistent for a decreased relaxation and suggest also an impairment in the smooth muscle cell function in diabetic arterioles. IdB 1056 exhibited an inhibitory effect on increased microvascular permeability and on leukocytes adhering to the venular vessels. Indeed, the treatment with IdB 1056 in diabetic hamsters pretreated or not with indometacin, a cyclooxygenase inhibitor, restored the relaxant responses to Ach and SNP. In conclusion, the effects of IdB 1056 observed in vivo at the microcirculatory level prevent the injury to endothelial cell function associated with diabetes and/or oxidative stress.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
481-5
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed-meshheading:7779146-Acetylcholine, pubmed-meshheading:7779146-Animals, pubmed-meshheading:7779146-Anthocyanins, pubmed-meshheading:7779146-Benzopyrans, pubmed-meshheading:7779146-Blood Glucose, pubmed-meshheading:7779146-Blood Pressure, pubmed-meshheading:7779146-Body Weight, pubmed-meshheading:7779146-Capillary Permeability, pubmed-meshheading:7779146-Cell Adhesion, pubmed-meshheading:7779146-Cricetinae, pubmed-meshheading:7779146-Diabetes Mellitus, Experimental, pubmed-meshheading:7779146-Diabetic Angiopathies, pubmed-meshheading:7779146-Indomethacin, pubmed-meshheading:7779146-Leukocytes, pubmed-meshheading:7779146-Male, pubmed-meshheading:7779146-Mesocricetus, pubmed-meshheading:7779146-Microcirculation, pubmed-meshheading:7779146-Microscopy, Fluorescence, pubmed-meshheading:7779146-Nitroprusside, pubmed-meshheading:7779146-Tannins
pubmed:year
1995
pubmed:articleTitle
Effects of the natural flavonoid delphinidin on diabetic microangiopathy.
pubmed:affiliation
CNR-Consiglio Nazionale delle Ricerche, Institute of Clinical Physiology, Milan, Italy.
pubmed:publicationType
Journal Article