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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1995-7-12
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pubmed:abstractText |
Infection by human immunodeficiency virus type 1 (HIV-1) causes acquired immunodeficiency syndrome (AIDS) after a long clinical latency. This disease is associated with a spectrum of cancers. Here we report that wild-type p53 is a potent suppressor of Tat, a major transactivator of HIV-1. Reciprocally, Tat inhibits the transcription of p53. Downregulation of p53 by upregulated tat may be important for the establishment of productive viral infection in a cell and also may be involved in the development of AIDS-related malignancies.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-1465435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-1480497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-1505019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-1552940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-2144057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-2157286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-2184372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-222475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-2664471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-2830675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-2845275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-2849510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-2981427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-3001360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-3321071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-6277513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-7935812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-8035494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-8121496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-8125909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-8134379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-8178724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-8221699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-8221889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-8254719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-8382357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-8387645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-8446597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7777531-8490957
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
92
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pubmed:geneSymbol |
p53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5461-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7777531-Base Sequence,
pubmed-meshheading:7777531-DNA, Complementary,
pubmed-meshheading:7777531-Down-Regulation,
pubmed-meshheading:7777531-Gene Products, tat,
pubmed-meshheading:7777531-Genes, p53,
pubmed-meshheading:7777531-Genes, tat,
pubmed-meshheading:7777531-HIV Long Terminal Repeat,
pubmed-meshheading:7777531-HIV-1,
pubmed-meshheading:7777531-Humans,
pubmed-meshheading:7777531-Molecular Sequence Data,
pubmed-meshheading:7777531-Promoter Regions, Genetic,
pubmed-meshheading:7777531-Transcriptional Activation,
pubmed-meshheading:7777531-Tumor Cells, Cultured,
pubmed-meshheading:7777531-Tumor Necrosis Factor-alpha,
pubmed-meshheading:7777531-Tumor Suppressor Protein p53,
pubmed-meshheading:7777531-tat Gene Products, Human Immunodeficiency Virus
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pubmed:year |
1995
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pubmed:articleTitle |
Reciprocal modulations between p53 and Tat of human immunodeficiency virus type 1.
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pubmed:affiliation |
Division of Cell Growth and Regulation, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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