Linked Life Data

7775979

Source:http://linkedlifedata.com/resource/pubmed/id/7775979

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-7-12
pubmed:abstractText
The photoaquation of the title compound [cis-Cr(phen)2CL+2] has been studied using high performance liquid chromatography. Both monoaquo [cis-Cr(phen)2Cl(OH2)2+2] and diaquo [cis-Cr(phen)2(OH2)3+2] products are formed, and the quantum efficiency for the loss of starting material in Tris buffer (pH 7) under argon and oxygen is 0.010 +/- 0.001 and 0.0026 +/- 0.0002, respectively. The presence of deoxyguanosine (dG) increases the rate of loss, as much as twofold under argon, but only the rate of diaquo product formation is enhanced by the nucleoside. The dG effect is attributed to reductive quenching of the cis-Cr(phen)2Cl+2 excited state by the base. Equilibrium dialysis studies indicate that both cis-Cr(phen)2Cl+2 and cis-Cr(phen)2(OH2)3+2 minimally associate with calf-thymus DNA. However, photolyses of cis-Cr(phen)2Cl+2 with the nucleic acid yield a mixture of unidentified covalent adducts. The diaquo complex also forms covalent adducts with DNA in the absence of light. Photolyses of the cis-Cr(phen)2Cl+2 with polyribonucleotides indicate a clear preference for covalent binding to the purines.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0162-0134
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
249-70
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Photoaquation of cis-dichlorobis-(1,10-phenanthroline)chromium(III) and the photochemical and thermal reactions of this complex with native calf-thymus DNA.
pubmed:affiliation
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907-1393, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.