Linked Life Data

7770669

Source:http://linkedlifedata.com/resource/pubmed/id/7770669

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-7-6
pubmed:abstractText
A finite element model of the dog lung, heart and abdomen, consisting of three solid linearly elastic bodies, was developed to study the effects of gravity on the vertical stress distribution and lung volume in different body positions at functional residual capacity (FRC). The geometry of the lung was obtained from an isolated dried dog lung after inflation to total lung capacity (TLC). The compliance of the rib cage, diaphragm and the abdomen was simulated by spring elements located on their surfaces. In the prone position, gravitational forces acting only on the lung contributed to the vertical gradient (0.19 cmH2O/cm) in transpulmonary pressure (Ptp). This result was independent of chest wall compliance. In the supine position, the addition of the heart and abdomen with a compliant diaphragm and abdominal walls increased the vertical Ptp gradient to 0.53 cmH2O/cm. In the head-up (upright) position, both heart and abdominal weight contributed to the vertical gradient (0.47 cmH2O/cm). Diaphragmatic compliance was of less importance to the vertical gradient in the head-up and head-down positions in the absence of the abdomen. The smallest vertical gradient (0.11 cmH2O/cm) was obtained in the head-down position with abdominal weight reducing the gradient caused by lung weight. Lung volume at FRC was virtually unaffected by gravity in the prone body position, was reduced by gravity in the supine and head-down positions but increased in the head-up position. The effects of a compliant diaphragm and abdominal weight are important contributors to the distribution of stress and volume in the intact lung.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0034-5687
pubmed:author
pubmed:issnType
Print
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
341-53
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
A finite element analysis of the effects of the abdomen on regional lung expansion.
pubmed:affiliation
Center for Biomedical Engineering, Wenner Gren Research Laboratory, University of Kentucky, Lexington 40506-0070, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.