Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1995-7-6
|
| pubmed:abstractText |
The effects of three doses (0.003, 0.03 and 1.0 mg/kg sc) of the 5-HT3 receptor antagonist, WAY 100289, on spatial learning and memory in the water maze were examined in rats before and after ibotenate lesions to the nucleus basalis and medial septal brain regions at the source of cholinergic projections to cortex and hippocampus. The representative cholinergic nicotinic and muscarinic receptor agonists nicotine (0.1 mg/kg) and arecoline (1.0 mg/kg) were also tested for comparison. Both arecoline and nicotine improved initial acquisition in rats before lesioning, in terms of latency to find a hidden platform and accuracy of search strategy. WAY100289 did not affect the performance of normal rats significantly, apart from some non-significant trends towards improvement with the highest dose. However, in animals showing transient navigational deficits in retention and relearning after lesioning, WAY100289 improved performance at all three doses, though ameliorative effects of nicotine and arecoline were more marked also in lesioned rats. These results show that WAY100289 improved spatial learning in animals impaired after lesions to cholinergic projection nuclei, which may reflect an interaction with cholinergic transmission to enhance cognitive function. However, in the present study, WAY100289 appeared to be less effective than direct cholinergic agonists.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arecoline,
http://linkedlifedata.com/resource/pubmed/chemical/Benzamides,
http://linkedlifedata.com/resource/pubmed/chemical/Bicyclo Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Bicyclo Compounds, Heterocyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Choline O-Acetyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Ibotenic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotine,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/WAY 100289
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0033-3158
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
117
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
318-32
|
| pubmed:dateRevised |
2009-9-29
|
| pubmed:meshHeading |
pubmed-meshheading:7770608-Animals,
pubmed-meshheading:7770608-Arecoline,
pubmed-meshheading:7770608-Autonomic Pathways,
pubmed-meshheading:7770608-Benzamides,
pubmed-meshheading:7770608-Bicyclo Compounds,
pubmed-meshheading:7770608-Bicyclo Compounds, Heterocyclic,
pubmed-meshheading:7770608-Choline O-Acetyltransferase,
pubmed-meshheading:7770608-Cues,
pubmed-meshheading:7770608-Ibotenic Acid,
pubmed-meshheading:7770608-Male,
pubmed-meshheading:7770608-Maze Learning,
pubmed-meshheading:7770608-Memory,
pubmed-meshheading:7770608-Memory, Short-Term,
pubmed-meshheading:7770608-Nicotine,
pubmed-meshheading:7770608-Parasympathetic Nervous System,
pubmed-meshheading:7770608-Prosencephalon,
pubmed-meshheading:7770608-Rats,
pubmed-meshheading:7770608-Rats, Sprague-Dawley,
pubmed-meshheading:7770608-Reversal Learning,
pubmed-meshheading:7770608-Serotonin Antagonists,
pubmed-meshheading:7770608-Space Perception
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
The selective 5-HT3 receptor antagonist, WAY100289, enhances spatial memory in rats with ibotenate lesions of the forebrain cholinergic projection system.
|
| pubmed:affiliation |
Department of Psychology, Institute of Psychiatry, London, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|