rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1995-7-6
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pubmed:databankReference |
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pubmed:abstractText |
The complete human 66 kd neurofilament cDNA was isolated and its sequence was determined. Both the DNA and the predicted amino acid sequences showed a high degree of homology to the rat NF-66. This was substantiated by cross hybridization between the human NF-66 probe and rat NF-66 mRNA. Single gene copy was suggested from Southern blot analysis. RNase protection assay indicated that NF-66 was expressed in human fetal brain as early as the 16th gestational week. On the other hand, NF-L message was not detected until the 20th gestational week. NF-M message was not detectable up to the 24th gestational week.
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pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0169-328X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
29
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
177-84
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:7769995-Amino Acid Sequence,
pubmed-meshheading:7769995-Animals,
pubmed-meshheading:7769995-Base Sequence,
pubmed-meshheading:7769995-Cloning, Molecular,
pubmed-meshheading:7769995-DNA, Complementary,
pubmed-meshheading:7769995-Embryonic and Fetal Development,
pubmed-meshheading:7769995-Fetus,
pubmed-meshheading:7769995-Humans,
pubmed-meshheading:7769995-Molecular Sequence Data,
pubmed-meshheading:7769995-Molecular Weight,
pubmed-meshheading:7769995-Neuroblastoma,
pubmed-meshheading:7769995-Neurofilament Proteins,
pubmed-meshheading:7769995-Rats,
pubmed-meshheading:7769995-Sequence Homology, Amino Acid,
pubmed-meshheading:7769995-Tumor Cells, Cultured
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pubmed:year |
1995
|
pubmed:articleTitle |
Cloning and developmental expression of human 66 kd neurofilament protein.
|
pubmed:affiliation |
Saul Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|