Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1995-7-5
|
| pubmed:abstractText |
Sodium butyrate (NaB), a physiologically produced short chain fatty acid, dramatically changes the growth rate and also the morphology of a fast growing subclone (N.1) derived from the heterogenous human ovarian carcinoma HOC-7. The mRNA of the growth related proto-oncogene c-myc, constitutively expressed in N.1 cells decreased significantly within 24 h of NaB treatment and remained suppressed until the NaB block was released. Down-regulation was accomplished partially by accelerating degradation of c-myc mRNA and by inhibiting splicing of c-myc transcripts. We demonstrated that NaB blocked general mechanisms in signal transduction, such as the release of Ca2+ from intracellular stores, and modulated the activity of serine/threonine kinases. The multiple effects of sodium butyrate on HOC-7 derivatives, as well as on a variety of other cell types investigated by others, may be due to interference with general mechanisms of signal transduction.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0143-3334
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:geneSymbol |
c-myc
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1199-205
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7767986-Adenocarcinoma,
pubmed-meshheading:7767986-Base Sequence,
pubmed-meshheading:7767986-Blotting, Northern,
pubmed-meshheading:7767986-Butyric Acid,
pubmed-meshheading:7767986-Butyric Acids,
pubmed-meshheading:7767986-Cell Line,
pubmed-meshheading:7767986-Cell Nucleus,
pubmed-meshheading:7767986-Cloning, Molecular,
pubmed-meshheading:7767986-DNA Primers,
pubmed-meshheading:7767986-Female,
pubmed-meshheading:7767986-Genes, myc,
pubmed-meshheading:7767986-Humans,
pubmed-meshheading:7767986-Introns,
pubmed-meshheading:7767986-Molecular Sequence Data,
pubmed-meshheading:7767986-Ovarian Neoplasms,
pubmed-meshheading:7767986-Polymerase Chain Reaction,
pubmed-meshheading:7767986-RNA, Messenger,
pubmed-meshheading:7767986-RNA Splicing,
pubmed-meshheading:7767986-Signal Transduction,
pubmed-meshheading:7767986-Transcription, Genetic,
pubmed-meshheading:7767986-Tumor Cells, Cultured
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Sodium butyrate inhibits c-myc splicing and interferes with signal transduction in ovarian carcinoma cells.
|
| pubmed:affiliation |
Ludwig Boltzmann Institute of Applied Cancer Research, 3rd Medical Department-Oncology, Kaiser Franz Josef-Hospital, Austria.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|