Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-7-5
pubmed:abstractText
Acrylamide is an alkylating agent which reacts very slowly in direct reactions with DNA and is negative in the Ames test, but is carcinogenic in mice and rats. In order to explain the cancer-initiating properties of acrylamide we have studied DNA adduct formation in vitro with a metabolizing system and in vivo in mice and rats following i.p. administration of 14C-labeled acrylamide. A major adduct found in both species was N-7-(2-carbamoyl-2-hydroxy-ethyl)guanine, formed by reaction of the DNA with the epoxide metabolite glycidamide. The levels of this adduct were similar in the different organs of the two rodent species, which supports the notion that glycidamide is relatively evenly distributed among tissues and that the organ-specificity in acrylamide carcinogenesis cannot be explained by a selective accumulation of the DNA-reactive metabolite in target organs.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0143-3334
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1161-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:7767980-Acrylamide, pubmed-meshheading:7767980-Acrylamides, pubmed-meshheading:7767980-Alkylating Agents, pubmed-meshheading:7767980-Animals, pubmed-meshheading:7767980-Brain, pubmed-meshheading:7767980-Carbon Radioisotopes, pubmed-meshheading:7767980-DNA, pubmed-meshheading:7767980-Epoxy Compounds, pubmed-meshheading:7767980-Guanine, pubmed-meshheading:7767980-Kidney, pubmed-meshheading:7767980-Liver, pubmed-meshheading:7767980-Lung, pubmed-meshheading:7767980-Magnetic Resonance Spectroscopy, pubmed-meshheading:7767980-Male, pubmed-meshheading:7767980-Mass Spectrometry, pubmed-meshheading:7767980-Mice, pubmed-meshheading:7767980-Mice, Inbred BALB C, pubmed-meshheading:7767980-Rats, pubmed-meshheading:7767980-Rats, Sprague-Dawley, pubmed-meshheading:7767980-Spleen, pubmed-meshheading:7767980-Testis, pubmed-meshheading:7767980-Tissue Distribution
pubmed:year
1995
pubmed:articleTitle
Formation of N-7-(2-carbamoyl-2-hydroxyethyl)guanine in DNA of the mouse and the rat following intraperitoneal administration of [14C]acrylamide.
pubmed:affiliation
Center for Nutrition and Toxicology, Karolinska Institute, Novum, Huddinge, Sweden.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.