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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-4-27
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pubmed:abstractText |
The effects of rat bile-pancreatic juice (BPJ) on Fe2+ induced oxidation of soybean phosphatidylcholine (PC) was monitored to investigate the influence of this digestive juice on oxidative damage in the gastrointestinal tract. A large volume of BPJ (50% in the suspension of PC, v/v) suppressed the lipid peroxidation, but a smaller volume had the reverse effect. BPJ could decompose free fatty acid hydroperoxides (FFA-OOH) at a lower concentration (approximately 0.2 mM) completely, although its phospholipase activity liberated FFA-OOH from PC hydroperoxides. Sodium deoxycholate enhanced the Fe2+ induced oxidation of PC in a concentration-dependent manner when PC was suspended in the buffer. Boiled BPJ suppressed Fe2+ induced and peroxyl radical initiated oxidation of sodium deoxycholate micelles of soybean PC up to approximately 50% (v/v). It was strongly suggested that rat BPJ had a biphasic effect on Fe2+ induced oxidation of phospholipids depending on the enhancement by bile salts and the inhibition by antioxidant components with radical-scavenging activity and hydroperoxide-decomposing activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
B
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/15-hydroperoxy-5,8,11,13-eicosatetra...,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxycholic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Ferrous Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Leukotrienes,
http://linkedlifedata.com/resource/pubmed/chemical/Lipid Peroxides,
http://linkedlifedata.com/resource/pubmed/chemical/Micelles,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylcholines,
http://linkedlifedata.com/resource/pubmed/chemical/Thiobarbituric Acid Reactive...
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0916-8451
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
55-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7765976-Animals,
pubmed-meshheading:7765976-Bile,
pubmed-meshheading:7765976-Chromatography, High Pressure Liquid,
pubmed-meshheading:7765976-Chromatography, Thin Layer,
pubmed-meshheading:7765976-Deoxycholic Acid,
pubmed-meshheading:7765976-Ferrous Compounds,
pubmed-meshheading:7765976-Leukotrienes,
pubmed-meshheading:7765976-Lipid Peroxidation,
pubmed-meshheading:7765976-Lipid Peroxides,
pubmed-meshheading:7765976-Male,
pubmed-meshheading:7765976-Micelles,
pubmed-meshheading:7765976-Oxidation-Reduction,
pubmed-meshheading:7765976-Pancreatic Juice,
pubmed-meshheading:7765976-Phosphatidylcholines,
pubmed-meshheading:7765976-Rats,
pubmed-meshheading:7765976-Rats, Wistar,
pubmed-meshheading:7765976-Soybeans,
pubmed-meshheading:7765976-Thiobarbituric Acid Reactive Substances
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pubmed:year |
1995
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pubmed:articleTitle |
Effects of rat bile-pancreatic juice on Fe2+ induced peroxidation of phospholipids.
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pubmed:affiliation |
National Food Research Institute, Ministry of Agriculture, Forestry, and Fisheries, Ibaraki, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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