| pubmed-article:7763262 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7763262 | lifeskim:mentions | umls-concept:C0079633 | lld:lifeskim |
| pubmed-article:7763262 | lifeskim:mentions | umls-concept:C0040845 | lld:lifeskim |
| pubmed-article:7763262 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7763262 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:7763262 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7763262 | pubmed:dateCreated | 1995-6-29 | lld:pubmed |
| pubmed-article:7763262 | pubmed:abstractText | We have studied the relationship between interleukin-8 (IL-8) and interleukin-1 alpha (IL-1 alpha) release after stimulation with all-trans retinoic acid (ATRA) and tumor necrosis factor-alpha (TNF-alpha) in the human epithelial ovarian cancer cell line HOC-7. Both IL-1 alpha and IL-8 protein release were enhanced by treatment with ATRA and TNF-alpha after 48 h exposure. Blocking of IL-1 alpha activity in HOC-7 cells with either IL-1 receptor antagonist (IL-1ra) or a neutralizing antibody directed against IL-1 alpha resulted in a dose-dependent decrease of IL-8 release by ATRA, TNF-alpha and IL-1 alpha treated HOC-7 cells. Expression of IL-8 mRNA was enhanced by the individual stimuli, whereas co-treatment with IL-1ra resulted in a loss of IL-8 specific transcripts, except in TNF-alpha treated cells. Inhibition of de novo protein synthesis by cycloheximide (CHX) and simultaneous blocking of IL-1 alpha activity by IL-1ra for 24 h revealed that ATRA controls IL-8 gene expression transcriptionally and that the extent of IL-8 protein release can be markedly influenced by cellular expressed IL-1 alpha. | lld:pubmed |
| pubmed-article:7763262 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7763262 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7763262 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7763262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7763262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7763262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7763262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7763262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7763262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7763262 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7763262 | pubmed:month | May | lld:pubmed |
| pubmed-article:7763262 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:7763262 | pubmed:author | pubmed-author:HuberHH | lld:pubmed |
| pubmed-article:7763262 | pubmed:author | pubmed-author:DittrichCC | lld:pubmed |
| pubmed-article:7763262 | pubmed:author | pubmed-author:BallaunCC | lld:pubmed |
| pubmed-article:7763262 | pubmed:author | pubmed-author:LindleyII | lld:pubmed |
| pubmed-article:7763262 | pubmed:author | pubmed-author:HarantHH | lld:pubmed |
| pubmed-article:7763262 | pubmed:author | pubmed-author:KrupitzaGG | lld:pubmed |
| pubmed-article:7763262 | pubmed:author | pubmed-author:GruntTT | lld:pubmed |
| pubmed-article:7763262 | pubmed:author | pubmed-author:UthmanAA | lld:pubmed |
| pubmed-article:7763262 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7763262 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:7763262 | pubmed:volume | 210 | lld:pubmed |
| pubmed-article:7763262 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7763262 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7763262 | pubmed:pagination | 898-906 | lld:pubmed |
| pubmed-article:7763262 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7763262 | pubmed:meshHeading | pubmed-meshheading:7763262-... | lld:pubmed |
| pubmed-article:7763262 | pubmed:meshHeading | pubmed-meshheading:7763262-... | lld:pubmed |
| pubmed-article:7763262 | pubmed:meshHeading | pubmed-meshheading:7763262-... | lld:pubmed |
| pubmed-article:7763262 | pubmed:meshHeading | pubmed-meshheading:7763262-... | lld:pubmed |
| pubmed-article:7763262 | pubmed:meshHeading | pubmed-meshheading:7763262-... | lld:pubmed |
| pubmed-article:7763262 | pubmed:meshHeading | pubmed-meshheading:7763262-... | lld:pubmed |
| pubmed-article:7763262 | pubmed:meshHeading | pubmed-meshheading:7763262-... | lld:pubmed |
| pubmed-article:7763262 | pubmed:meshHeading | pubmed-meshheading:7763262-... | lld:pubmed |
| pubmed-article:7763262 | pubmed:meshHeading | pubmed-meshheading:7763262-... | lld:pubmed |
| pubmed-article:7763262 | pubmed:meshHeading | pubmed-meshheading:7763262-... | lld:pubmed |
| pubmed-article:7763262 | pubmed:meshHeading | pubmed-meshheading:7763262-... | lld:pubmed |
| pubmed-article:7763262 | pubmed:meshHeading | pubmed-meshheading:7763262-... | lld:pubmed |
| pubmed-article:7763262 | pubmed:meshHeading | pubmed-meshheading:7763262-... | lld:pubmed |
| pubmed-article:7763262 | pubmed:meshHeading | pubmed-meshheading:7763262-... | lld:pubmed |
| pubmed-article:7763262 | pubmed:meshHeading | pubmed-meshheading:7763262-... | lld:pubmed |
| pubmed-article:7763262 | pubmed:meshHeading | pubmed-meshheading:7763262-... | lld:pubmed |
| pubmed-article:7763262 | pubmed:meshHeading | pubmed-meshheading:7763262-... | lld:pubmed |
| pubmed-article:7763262 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7763262 | pubmed:articleTitle | Regulation of interleukin-8 gene expression by all-trans retinoic acid. | lld:pubmed |
| pubmed-article:7763262 | pubmed:affiliation | Department of Internal Medicine I, University Hospital of Vienna, Austria. | lld:pubmed |
| pubmed-article:7763262 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7763262 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7763262 | lld:pubmed |
