| pubmed-article:7763236 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7763236 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7763236 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:7763236 | lifeskim:mentions | umls-concept:C1366557 | lld:lifeskim |
| pubmed-article:7763236 | lifeskim:mentions | umls-concept:C1704256 | lld:lifeskim |
| pubmed-article:7763236 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:7763236 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:7763236 | lifeskim:mentions | umls-concept:C0041637 | lld:lifeskim |
| pubmed-article:7763236 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:7763236 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7763236 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7763236 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7763236 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7763236 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7763236 | pubmed:dateCreated | 1995-6-29 | lld:pubmed |
| pubmed-article:7763236 | pubmed:abstractText | Transforming growth factor beta 1 (TGF-beta 1) is a potent growth inhibitor of human umbilical vein endothelial cells (HUVEC). We investigated whether apoptosis is involved in the TGF-beta 1 mediated HUVEC growth inhibition. Using immunofluorescence microscopy and staining by propidium iodide, we showed HUVEC treated with TGF-beta 1 contained characteristic apoptotic nuclei with condensation of chromatin. FACS analysis demonstrated that the number of cells with hypodiploid DNA contents were increased in HUVEC treated with TGF-beta 1. The DNA fragmentation assay exhibited typical ladder formation in TGF-beta 1-treated HUVEC. Using Western blot analysis, the expression of bcl-2 on HUVEC was down-regulated by TGF-beta 1-treatment. These findings suggest that TGF-beta 1 regulates the growth of HUVEC by inducing apoptosis accompanied with down-regulation of bcl-2 expression. | lld:pubmed |
| pubmed-article:7763236 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7763236 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7763236 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7763236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7763236 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7763236 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7763236 | pubmed:month | May | lld:pubmed |
| pubmed-article:7763236 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:7763236 | pubmed:author | pubmed-author:TsukadaTT | lld:pubmed |
| pubmed-article:7763236 | pubmed:author | pubmed-author:KawabeYY | lld:pubmed |
| pubmed-article:7763236 | pubmed:author | pubmed-author:MatsuokaNN | lld:pubmed |
| pubmed-article:7763236 | pubmed:author | pubmed-author:NagatakiSS | lld:pubmed |
| pubmed-article:7763236 | pubmed:author | pubmed-author:MizokamiAA | lld:pubmed |
| pubmed-article:7763236 | pubmed:author | pubmed-author:EguchiKK | lld:pubmed |
| pubmed-article:7763236 | pubmed:author | pubmed-author:TakashimaHH | lld:pubmed |
| pubmed-article:7763236 | pubmed:author | pubmed-author:KawakamiAA | lld:pubmed |
| pubmed-article:7763236 | pubmed:author | pubmed-author:MigitaKK | lld:pubmed |
| pubmed-article:7763236 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7763236 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:7763236 | pubmed:volume | 210 | lld:pubmed |
| pubmed-article:7763236 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7763236 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7763236 | pubmed:pagination | 1076-82 | lld:pubmed |
| pubmed-article:7763236 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7763236 | pubmed:meshHeading | pubmed-meshheading:7763236-... | lld:pubmed |
| pubmed-article:7763236 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7763236 | pubmed:articleTitle | Transforming growth factor beta 1 induces apoptotic cell death in cultured human umbilical vein endothelial cells with down-regulated expression of bcl-2. | lld:pubmed |
| pubmed-article:7763236 | pubmed:affiliation | First Department of Internal Medicine, Nagasaki University School of Medicine, Japan. | lld:pubmed |
| pubmed-article:7763236 | pubmed:publicationType | Journal Article | lld:pubmed |
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