|
rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
6
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pubmed:dateCreated |
1995-6-23
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|
pubmed:abstractText |
Intra-abdominal abscess is seldom adequately treated by systemic antibiotics alone and often requires surgical or computed tomography-guided drainage for resolution. Abscess penetration of six currently used antibiotics was examined in a murine intra-abdominal abscess model. Ampicillin/sulbactam, cefmetazole, clindamycin, and trospectomycin penetrated intra-abdominal abscesses to a greater degree than cefoxitin and ceftriaxone. Abscess pus antibiotic levels were not significantly higher after multiple doses than after a single dose. Pus antibiotic levels below the MIC90 for Bacteroides and E. coli within intra-abdominal abscess were observed for most antibiotics with the doses used in this study. Selection of antibiotics with a greater ability to penetrate abscess may be important in optimally treating patients with abdominal infection.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0003-1348
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
521-5
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7762902-Abdominal Abscess,
pubmed-meshheading:7762902-Ampicillin,
pubmed-meshheading:7762902-Animals,
pubmed-meshheading:7762902-Anti-Bacterial Agents,
pubmed-meshheading:7762902-Bacteroides Infections,
pubmed-meshheading:7762902-Bacteroides fragilis,
pubmed-meshheading:7762902-Cefmetazole,
pubmed-meshheading:7762902-Cefoxitin,
pubmed-meshheading:7762902-Ceftriaxone,
pubmed-meshheading:7762902-Clindamycin,
pubmed-meshheading:7762902-Drug Evaluation, Preclinical,
pubmed-meshheading:7762902-Drug Therapy, Combination,
pubmed-meshheading:7762902-Escherichia coli Infections,
pubmed-meshheading:7762902-Hydrogen-Ion Concentration,
pubmed-meshheading:7762902-Male,
pubmed-meshheading:7762902-Mice,
pubmed-meshheading:7762902-Microbial Sensitivity Tests,
pubmed-meshheading:7762902-Spectinomycin,
pubmed-meshheading:7762902-Sulbactam
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pubmed:year |
1995
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|
pubmed:articleTitle |
Antibiotic penetration of experimental intra-abdominal abscesses.
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|
pubmed:affiliation |
Department of Surgery, University of Louisville School of Medicine, KY 40292, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
