Linked Life Data

7761994

Source:http://linkedlifedata.com/resource/pubmed/id/7761994

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1995-6-29
pubmed:abstractText
The effect of 3,4,5,6-tetrachloro-2',4',5',7'-tetraiodo-fluorescein sodium salt (Rose Bengal B or FD&C Red No. 105, molecular weight 1017.6) on the thyroid of rats treated with N-bis(2-hydroxypropyl)-nitrosamine (DHPN) and iodine-deficient (I-def) diet is studied. Six-week-old male F344 rats were divided into seven groups (20 each) and given a single subcutaneous injection of DHPN (2800 mg/kg body wt.). From week 2 to 20, I-def diet was given in combination with either FR105 (1.25, 5.0, or 20 mg/l) or potassium iodide (KI, 12.5, 50.0 or 200 micrograms/l) in drinking water. As a result, an amount of 1.25 mg/l of FR105 was slightly more effective than 200 micrograms/l of KI in terms of inhibition of the effect of I-def diet on thyroid weight, morphology, thyroid-related hormones and thyroid tumor development. It was calculated that 1 mumol/l of FR105 was slightly more potent than 1 mumol/l of iodide ion. As each FR105 molecule has four iodide residues, at least 25% of total iodide residues were calculated to be utilized by the rats given I-def diet.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0300-483X
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
107-13
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
FD&C Red No. 105 (Rose Bengal B) neutralizes the thyroid tumor promoting effect of iodine-deficient diet in rats.
pubmed:affiliation
Department of Pathology, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't