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rdf:type |
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lifeskim:mentions |
|
|
pubmed:issue |
5215
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pubmed:dateCreated |
1995-6-29
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|
pubmed:abstractText |
Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jun
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pubmed:issn |
0036-8075
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|
pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
2
|
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pubmed:volume |
268
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
N
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pubmed:pagination |
1343-7
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:7761853-Animals,
pubmed-meshheading:7761853-Antigen-Presenting Cells,
pubmed-meshheading:7761853-Cytotoxicity, Immunologic,
pubmed-meshheading:7761853-Fibroblasts,
pubmed-meshheading:7761853-Glycoproteins,
pubmed-meshheading:7761853-Histocompatibility Antigens Class I,
pubmed-meshheading:7761853-L Cells (Cell Line),
pubmed-meshheading:7761853-Lymphocytic Choriomeningitis,
pubmed-meshheading:7761853-Lymphocytic choriomeningitis virus,
pubmed-meshheading:7761853-Lymphoid Tissue,
pubmed-meshheading:7761853-Mice,
pubmed-meshheading:7761853-Mice, Inbred C57BL,
pubmed-meshheading:7761853-Neoplasms,
pubmed-meshheading:7761853-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:7761853-Transfection,
pubmed-meshheading:7761853-Tumor Cells, Cultured,
pubmed-meshheading:7761853-Viral Proteins
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pubmed:year |
1995
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|
pubmed:articleTitle |
Fibroblasts as efficient antigen-presenting cells in lymphoid organs.
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pubmed:affiliation |
Institute of Experimental Immunology, University of Zürich, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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