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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1995-6-29
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pubmed:abstractText |
We have developed a system for studying hepatocellular growth potential in which liver cells are introduced into the diseased livers of albumin-urokinase (Alb-uPA) transgenic mice. To use this system to study xenogeneic cell transplantation, rat liver cells were introduced into immunotolerant Alb-uPA transgenic mice. In regenerated recipient livers, up to 100% of hepatocellular gene expression was of rat origin, demonstrating the creation of a functional mouse liver in which parenchyma is derived from xenogeneic (rat) hepatocytes. Immunotolerant Alb-uPA transgenic mice provide a tool for studying hepatocellular biology of any species, including humans, in a controlled experimental setting.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761429-1325126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761429-1693878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761429-1713128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761429-2410100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761429-2432143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761429-2442852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761429-2992937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761429-6195698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761429-6273298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761429-6344992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761429-8000434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761429-8108734
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4942-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:7761429-Animals,
pubmed-meshheading:7761429-Base Sequence,
pubmed-meshheading:7761429-Cell Transplantation,
pubmed-meshheading:7761429-DNA,
pubmed-meshheading:7761429-Female,
pubmed-meshheading:7761429-Immunohistochemistry,
pubmed-meshheading:7761429-Liver,
pubmed-meshheading:7761429-Liver Regeneration,
pubmed-meshheading:7761429-Male,
pubmed-meshheading:7761429-Mice,
pubmed-meshheading:7761429-Mice, Nude,
pubmed-meshheading:7761429-Mice, Transgenic,
pubmed-meshheading:7761429-Molecular Sequence Data,
pubmed-meshheading:7761429-Oligonucleotide Probes,
pubmed-meshheading:7761429-RNA, Messenger,
pubmed-meshheading:7761429-Rats,
pubmed-meshheading:7761429-Rats, Sprague-Dawley,
pubmed-meshheading:7761429-Recombinant Fusion Proteins,
pubmed-meshheading:7761429-Serum Albumin,
pubmed-meshheading:7761429-Transferrin,
pubmed-meshheading:7761429-Transplantation, Heterologous,
pubmed-meshheading:7761429-Urokinase-Type Plasminogen Activator
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pubmed:year |
1995
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pubmed:articleTitle |
Complete reconstitution of mouse liver with xenogeneic hepatocytes.
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pubmed:affiliation |
Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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