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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1995-6-29
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pubmed:databankReference |
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pubmed:abstractText |
By screening a cDNA library constructed from aortic total RNA derived from Watanabe heritable hyperlipidemic (WHHL) rabbits by differential hybridization, we have obtained a cDNA encoding the kappa light chain of immunoglobulin. Northern blot analysis of total RNA prepared from aortas of WHHL and normal rabbits of various ages revealed that this light-chain mRNA accumulates gradually with age in aortas in WHHL rabbits. Northern blotting and in situ hybridization with an antisense oligonucleotide specific to rabbit immunoglobulin gamma heavy-chain mRNA also detected accumulation of this heavy-chain mRNA in advanced lesions of WHHL rabbit aortas. Moreover, immunohistochemical and electron microscopic analyses demonstrated the presence of plasma cells in the atherosclerotic lesions.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-2029509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-2071894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-2312724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-2461560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-2505620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-2599005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-3010466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-3297675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-6198242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-6264472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-6312838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-6410392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-6438436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-6824499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-7406953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-7820873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-7883748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7761428-8479518
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4937-41
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7761428-Amino Acid Sequence,
pubmed-meshheading:7761428-Animals,
pubmed-meshheading:7761428-Aorta,
pubmed-meshheading:7761428-Arteriosclerosis,
pubmed-meshheading:7761428-Base Sequence,
pubmed-meshheading:7761428-Blotting, Northern,
pubmed-meshheading:7761428-DNA Primers,
pubmed-meshheading:7761428-Gene Expression,
pubmed-meshheading:7761428-Homozygote,
pubmed-meshheading:7761428-Hyperlipidemias,
pubmed-meshheading:7761428-Immunoglobulin gamma-Chains,
pubmed-meshheading:7761428-Immunoglobulin kappa-Chains,
pubmed-meshheading:7761428-In Situ Hybridization,
pubmed-meshheading:7761428-Molecular Sequence Data,
pubmed-meshheading:7761428-Muscle, Smooth, Vascular,
pubmed-meshheading:7761428-Oligodeoxyribonucleotides,
pubmed-meshheading:7761428-Oligonucleotides, Antisense,
pubmed-meshheading:7761428-Plasma Cells,
pubmed-meshheading:7761428-Polymerase Chain Reaction,
pubmed-meshheading:7761428-RNA, Messenger,
pubmed-meshheading:7761428-Rabbits,
pubmed-meshheading:7761428-Reference Values
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pubmed:year |
1995
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pubmed:articleTitle |
Accumulation of plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.
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pubmed:affiliation |
Tohoku University Gene Research Center, Tohoku University, Sendai, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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