Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-6-23
pubmed:abstractText
T cells are made tolerant only to those self-peptides that are presented in sufficient amounts by antigen-presenting cells. They ignore cryptic self-determinants, such as either those not generated by processing machinery or generated in insufficient amounts. It is anticipated that mechanisms that either change antigen processing or increase the yield of previously "invisible" peptides may be capable of inducing T cell priming and, if they are self-maintained, may sustain autoimmune diseases. Herein, we demonstrate for the first time a mechanism by which the gp120 human immunodeficiency virus-I, by downregulating plasma membrane CD4 and increasing its processing, unveils hidden CD4 epitopes, inducing an autoimmune-specific T cell response.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-1381399, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-1569393, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-1574119, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-1674746, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-1676268, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-1677809, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-1709661, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-1849799, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-1910679, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-2188679, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-2477450, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-2478888, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-2541442, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-2555159, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-2829024, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-2841610, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-2969774, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-7517364, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-7539032, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-7682817, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-7686009, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-7690836, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-7909813, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-8093551, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-8098942, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-8145041, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-8177315, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-8177316, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-8177317, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-8177319, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-8280459, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-8293461, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-8293464, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-8300557, http://linkedlifedata.com/resource/pubmed/commentcorrection/7760011-8381158
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
181
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2253-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
HIVgp120 activates autoreactive CD4-specific T cell responses by unveiling of hidden CD4 peptides during processing.
pubmed:affiliation
Istituto I Clinica Medica, Policlinico Umberto I, Università di Roma La Sapienza, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't