Linked Life Data

7759960

Source:http://linkedlifedata.com/resource/pubmed/id/7759960

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-6-28
pubmed:abstractText
We have studied two key stages of CD4 development that serve as important checkpoints in determining whether a response will occur, how big it will be, and how long it will last. The response of naive CD4 cells is strictly regulated by the requirement for interaction of the potential precursor with an antigen-presenting cell-expressing multiple costimulatory molecules such as B7 family and intercellular adhesion molecule-1. The extent of naive cell proliferation is critically dependent on interleukin-2, whose autocrine production is similarly regulated. We show that effector CD4 cells can either die, expand, and/or generate memory. Antigen stimulation accelerates death or promotes expansion dependent on the presence of cytokines. Interleukin-2 and transforming growth factor-beta synergize to block apoptosis and favor extensive effector expansion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0741-5400
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
795-8
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
CD4 T cell development and cytokine polarization: an overview.
pubmed:affiliation
Department of Biology, University of California, San Diego, La Jolla, 92093-0063, USA.
pubmed:publicationType
Journal Article, Review