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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1995-6-29
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pubmed:abstractText |
COL5A1, the gene for the alpha 1 chain of type V collagen, has been considered a candidate gene for certain diseases based on chromosomal location and/or disease phenotype. We have employed 3'-untranslated region RFLPs to exclude COL5A1 as a candidate gene in families with tuberous sclerosis 1, Ehlers-Danlos syndrome type II, and nail-patella syndrome. In addition, we describe a polymorphic simple sequence repeat (SSR) within a COL5A1 intron. This SSR is used to exclude COL5A1 as a candidate gene in hereditary hemorrhagic telangiectasia (Osler-Rendu-Weber disease) and to add COL5A1 to the existing map of "index" markers of chromosome 9 by evaluation of the COL5A1 locus on the CEPH 40-family reference pedigree set. This genetic mapping places COL5A1 between markers D9S66 and D9S67.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0888-7543
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
25
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pubmed:geneSymbol |
COL5A1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
737-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7759113-Base Sequence,
pubmed-meshheading:7759113-Chromosomes, Human, Pair 9,
pubmed-meshheading:7759113-Collagen,
pubmed-meshheading:7759113-DNA,
pubmed-meshheading:7759113-Ehlers-Danlos Syndrome,
pubmed-meshheading:7759113-Humans,
pubmed-meshheading:7759113-Molecular Sequence Data,
pubmed-meshheading:7759113-Nail-Patella Syndrome,
pubmed-meshheading:7759113-Polymorphism, Genetic,
pubmed-meshheading:7759113-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:7759113-Telangiectasia, Hereditary Hemorrhagic,
pubmed-meshheading:7759113-Tuberous Sclerosis
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pubmed:year |
1995
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pubmed:articleTitle |
COL5A1: fine genetic mapping and exclusion as candidate gene in families with nail-patella syndrome, tuberous sclerosis 1, hereditary hemorrhagic telangiectasia, and Ehlers-Danlos Syndrome type II.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison 53706, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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