Linked Life Data

7759059

Source:http://linkedlifedata.com/resource/pubmed/id/7759059

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-6-29
pubmed:abstractText
In K-loaded intact and nephrectomized control dogs there is a four-to five-fold increase of basal serum insulin. With beta receptor blockade in K-loaded intact animals the increase of basal serum insulin is less than 1/4 to that in controls; in those with nephrectomy, the increase is similar to that in controls. Cervical vagotomy in K-loaded intact dogs does not alter (influence) the increase of serum insulin; in those with nephrectomy there is a striking increase. In K-loaded intact dogs cervical vagotomy added to beta receptor blockade has no influence i.e., the response is the same as that to blockade alone; in those with nephrectomy, the increase produced by vagotomy is suppressed. Results suggest that in controls with nephrectomy, the insulin secretory response does not involve beta receptors of pancreatic islet B cells owing to restraint by efferent impulses in the cervical vagi. Interruption of the impulse by vagotomy releases the restraint, with resulting hyperactivity; the accompanying hyperinsulinemia may be the result of suppression of the hyperactive receptors by beta receptor blockade.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0018-5043
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
67-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Vagal modulation of the insulin secretory response to KCl loading in nephrectomized dogs.
pubmed:affiliation
Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't