Linked Life Data

7758212

Source:http://linkedlifedata.com/resource/pubmed/id/7758212

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1995-6-23
pubmed:abstractText
Red blood cells and plasma reduced and oxidized glutathione levels, glutathione peroxidase (GSH-Px) activity, thiobarbituric acid reactants (TBAR) of both chronic ambulatory peritoneal dialysis (CAPD) patients and a matched control group were investigated in this study. Oxidized and reduced pyridinic nucleotides in red blood cells (RBC), in which NADPH is a direct expression of hexose monophosphate shunt function, were also studied. The results obtained indicate that RBC and plasma are exposed to oxidative stress in CAPD. This condition is characterized by a decreased GSH/GSSG ratio, particularly evident in RBC as a consequence of the GSSG accumulation. Lipid peroxidation is increased, as indicated by raised TBAR levels, and reduced pyridinic nucleotides are decreased. Increased GSH-Px levels and unmodified or slightly increased GSH content were observed in the RBC but not in plasma, which showed decreased GSH and unmodified peroxidase activity. Peroxidase correlated positively with TBAR levels in the RBC lysates. In a subgroup of patients treated with erythropoietin (vs. untreated patients and controls) no differences were observed in the glutathione-related parameters studied. These data suggest that a mechanism for adaptation to oxidative conditions may be present in CAPD and its effects on RBC integrity are discussed in comparison with the hemodialysis conditions previously studied.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0009-8981
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
234
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-36
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed-meshheading:7758212-Adult, pubmed-meshheading:7758212-Aged, pubmed-meshheading:7758212-Antioxidants, pubmed-meshheading:7758212-Blood Proteins, pubmed-meshheading:7758212-Erythrocytes, pubmed-meshheading:7758212-Female, pubmed-meshheading:7758212-Glutathione, pubmed-meshheading:7758212-Glutathione Peroxidase, pubmed-meshheading:7758212-Hemoglobins, pubmed-meshheading:7758212-Humans, pubmed-meshheading:7758212-Kidney Failure, Chronic, pubmed-meshheading:7758212-Lipid Peroxides, pubmed-meshheading:7758212-Male, pubmed-meshheading:7758212-Middle Aged, pubmed-meshheading:7758212-NAD, pubmed-meshheading:7758212-NADP, pubmed-meshheading:7758212-Oxidation-Reduction, pubmed-meshheading:7758212-Pentose Phosphate Pathway, pubmed-meshheading:7758212-Peritoneal Dialysis, Continuous Ambulatory, pubmed-meshheading:7758212-Thiobarbituric Acid Reactive Substances
pubmed:year
1995
pubmed:articleTitle
Redox state, antioxidative activity and lipid peroxidation in erythrocytes and plasma of chronic ambulatory peritoneal dialysis patients.
pubmed:affiliation
Institute of Biochemistry G. Fornaini, University of Urbino, Italy.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial