Linked Life Data

7758130

Source:http://linkedlifedata.com/resource/pubmed/id/7758130

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-6-28
pubmed:abstractText
The effects of oral administration of methylated bovine serum albumin (mBSA) on antigen-induced arthritis (AIA) in rats that was induced by immunization with mBSA followed by the intraarticular injection of the same antigen were investigated. When mBSA was orally given to animals before immunization with the antigen, the development of AIA was markedly suppressed. In contrast, feeding mBSA after immunization or after intraarticular challenge was not effective in affecting the progression of arthritis. Delayed-type hypersensitivity and in vitro T cell proliferative responses to mBSA were also significantly downregulated in rats fed the antigen before, but not after immunization. These results indicate that the suppression of AIA by mBSA given before immunization appears to be due to the induction of tolerance to the oral antigen. No influence of mBSA administered orally after immunization on AIA as well as delayed-type hypersensitivity and proliferative responses to the antigen suggests that animals resist to be tolerant against an oral antigen when immune responses to the antigen already exist.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0008-8749
pubmed:author
pubmed:issnType
Print
pubmed:volume
163
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
55-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Antigen-induced arthritis in rats is suppressed by the inducing antigen administered orally before, but not after immunization.
pubmed:affiliation
Department of Microbiology, Saga Medical School, Japan.
pubmed:publicationType
Journal Article