Linked Life Data

7755892

Source:http://linkedlifedata.com/resource/pubmed/id/7755892

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1995-6-29
pubmed:abstractText
Memory formation following learning is presumed to result from modification in the efficacy of neural circuitry, either through strengthening of pre-existing synapses, or formation of new contacts. An ideal paradigm to investigate memory formation is one-trial passive avoidance training of day-old chicks, in which the birds learn to avoid pecking a bead coated with an aversive substance, methylanthranilate. Following training, a sequence of biochemical, electro-physiological, pharmacological and morphological events takes place within two loci in the forebrain, the intermediate and medial hyperstriatum ventrale (IMHV), and part of the paleostriatal complex, the lobus parolfactorius (LPO). Our data reviewed here suggest that the initial acquisition of memory involves population changes in the fine spatial organization of synaptic vesicles and active zones in synapses in the IMHV whereas longer-term changes are more prominent in the LPO and involve, primarily, a bilateral increase in the density of synapses and dendritic spines. The short-term synaptic changes are as dynamic as the molecular changes which have hitherto been considered the preserve of short-term correlates of memory formation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0166-4328
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-8
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Morphological changes associated with stages of memory formation in the chick following passive avoidance training.
pubmed:affiliation
Department of Biology, Open University, Milton Keynes, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't