Linked Life Data

7755609

Source:http://linkedlifedata.com/resource/pubmed/id/7755609

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-6-21
pubmed:abstractText
We investigated the levels of amyloid precursor protein (APP) and beta-amyloid peptide (A beta) in the cerebrospinal fluid (CSF) from 110 individuals ranging in age from newborn to 82-years old to analyze their regulation with age. These samples were segregated into two groups; one group contained CSF samples from patients with diagnosed CNS abnormalities and the second group contained CSF samples from patients with no known CNS disorders. The presence of APP and A beta was detected in all ages and from both CSF groups. No significant difference in the average level of A beta or APP was noted from either group with a change in age. However, a positive correlation was found to exist between levels of APP and A beta in individuals 25 years and older, suggesting that APP and A beta processing in the CSF is developmentally regulated. This observation was observed for both CSF groups.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
210
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
345-9
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
An age-related correlation between levels of beta-amyloid precursor protein and beta-amyloid in human cerebrospinal fluid.
pubmed:affiliation
Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48106, USA.
pubmed:publicationType
Journal Article