Linked Life Data

7755471

Source:http://linkedlifedata.com/resource/pubmed/id/7755471

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1995-6-22
pubmed:abstractText
Angiotensin II may act as an angiogenic and growth promoting factor on different cell types. To assess the role of angiotensin II on the compensatory renal response of the remnant kidney to unilateral nephrectomy (UNX), we measured renin, angiotensinogen, and angiotensin II type 1 receptor (AT1) mRNA levels as well as angiotensin II receptor density in 2 groups of 7 Sprague-Dawley rats 7 days after either shamp operation or UNX, Following UNX, the ratio of kidney weight to body weight (KW/BW) increased from 0.38 +/- 0.01 to 0.46 +/- 0.01% (p < 0.01). Neither renin (kidney) or angiotensiongen (kidney and liver) mRNA levels, determined by slot blot hybridization, changed after UNX. Angiotensin II receptor density was determined using an 125I-Sar1-Ile8 Ang II in situ receptor binding assay on fixed kidney sections. Binding specificity was verified using unlabeled Sar1-Ang II. Glomerular angiotensin II receptor density did not change significantly after UNX, nor did AT1 receptor mRNA. Thus, these data do not support a critical role for angiotensin II in the compensatory renal growth following uninephrectomy.
pubmed:grant
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0003-9683
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1115-7
pubmed:dateRevised
2009-2-13
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
[Gene expression of the renin-angiotensin system in compensatory renal hypertrophy secondary to contralateral nephrectomy].
pubmed:affiliation
Division of Nephrology, San Francisco General Hospital, University of California, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., English Abstract, Research Support, Non-U.S. Gov't