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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1995-6-16
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pubmed:abstractText |
beta-Amyloid deposition and neurofibrillary tangle formation are two histopathological features of Alzheimer disease. We have previously reported that beta-amyloid immunoreactive deposits form in the brains of transgenic mice programmed for neuronal expression of the 751-amino acid isoform of human beta-amyloid precursor protein (beta-APP751) and now describe that these animals also display Alz50 intraneuronal immunoreactivity similar to that seen in early Alzheimer disease. This suggests that abnormal beta-APP expression and/or beta-amyloid deposition promotes pathogenic alterations in tau protein. The frequency of both beta-amyloid deposition and Alz50-positive neurons was twice as prevalent in brains from old (22 months) as compared to young (2-3 months) beta-APP751 transgenic mice. This increase in histopathology with age in beta-APP751 transgenic mice parallels the time-dependent progression seen in the human disease.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-1530909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-1673681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-1786532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-1899488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-1906990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-2071697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-2106330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-2111579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-2116006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-2432180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-2483104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-2521927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-2522541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-2524150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-2583112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-2881207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-2908447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-2969441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-2970636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-3083509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-3131773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-3435070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-3930508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-4271339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7753818-7513982
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4402-6
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7753818-Alzheimer Disease,
pubmed-meshheading:7753818-Amyloid beta-Peptides,
pubmed-meshheading:7753818-Amyloid beta-Protein Precursor,
pubmed-meshheading:7753818-Animals,
pubmed-meshheading:7753818-Base Sequence,
pubmed-meshheading:7753818-DNA Primers,
pubmed-meshheading:7753818-Gene Expression,
pubmed-meshheading:7753818-Humans,
pubmed-meshheading:7753818-Immunohistochemistry,
pubmed-meshheading:7753818-Mice,
pubmed-meshheading:7753818-Mice, Transgenic,
pubmed-meshheading:7753818-Molecular Sequence Data,
pubmed-meshheading:7753818-Phosphopyruvate Hydratase,
pubmed-meshheading:7753818-Polymerase Chain Reaction,
pubmed-meshheading:7753818-Promoter Regions, Genetic,
pubmed-meshheading:7753818-RNA, Messenger,
pubmed-meshheading:7753818-Reference Values
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pubmed:year |
1995
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pubmed:articleTitle |
Early Alzheimer disease-like histopathology increases in frequency with age in mice transgenic for beta-APP751.
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pubmed:affiliation |
Scios Nova Inc., Mountain View, CA 94043, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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