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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
|
pubmed:dateCreated |
1995-6-21
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pubmed:abstractText |
Cytokine genes encode proteins that modulate immune system responses. Modification of tumor cells by the introduction of cytokine genes has been used as a strategy to augment host immunity. Interleukin 7 (IL-7) gene transfer enhances the immune response to tumor cells and can result in tumor regression. Transforming growth factor-beta 1 (TGF-beta 1) is a potent immunosuppressive cytokine produced by many tumors. We have previously reported that recombinant IL-7 decreases the expression of TGF-beta 1 by murine macrophages.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
|
pubmed:issn |
0027-8874
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
19
|
pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
593-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7752257-Animals,
pubmed-meshheading:7752257-Fibrosarcoma,
pubmed-meshheading:7752257-Gene Expression,
pubmed-meshheading:7752257-Gene Transfer Techniques,
pubmed-meshheading:7752257-Interleukin-7,
pubmed-meshheading:7752257-Lymphocyte Activation,
pubmed-meshheading:7752257-Mice,
pubmed-meshheading:7752257-Neoplasms, Experimental,
pubmed-meshheading:7752257-RNA, Messenger,
pubmed-meshheading:7752257-Transforming Growth Factor beta,
pubmed-meshheading:7752257-Tumor Cells, Cultured
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pubmed:year |
1995
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pubmed:articleTitle |
Down-regulation of murine fibrosarcoma transforming growth factor-beta 1 expression by interleukin 7.
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pubmed:affiliation |
Pulmonary Immunology Laboratory, UCLA School of Medicine, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|