|
pubmed:otherAbstract |
PIP: During October 1991 to March 1993, in Guatemala, clinical researchers conducted a randomized, double-blind, placebo-controlled clinical trial of 263 pediatric patients aged 3-48 months at the Hospital Roosevelt and the Guatemalteco Social Security Institute Hospital, both in Guatemala City. They aimed to determine the efficacy of a high dose of vitamin A (100,000 IU for children under 1 year of age and 200,000 IU for older children) as adjuvant treatment for radiographically confirmed cases of non-measles-related acute lower respiratory tract infection (ALRI). All the children received standard treatment for ALRI (antibiotics, oxygen, bronchodilators, and intravenously administered solutions). 132 children also received vitamin A and 131 received a placebo. Clinicians evaluated the childrens' condition every 8 hours. The two groups were essentially the same in duration of hospitalization; the rate of normalization in the respiratory rate, oxygen saturation, temperature, and clinical score; and adverse outcomes (mechanical ventilation, prolonged hospitalization, readmission or transfer, and death). These findings indicate that high doses of vitamin A in addition to standard treatment for non-measles-related ALRI lack efficacy for the current ALRI episode.
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
