Linked Life Data

7751915

Source:http://linkedlifedata.com/resource/pubmed/id/7751915

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5 Pt 1
pubmed:dateCreated
1995-6-20
pubmed:abstractText
Actions of adenosine triphosphate (ATP) on neurons of the substantia gelatinosa (SG) were evaluated in spinal cord slices using tight-seal, whole-cell recordings. Bath-applied ATP activated a fast inward current and potentiated both glutamate-induced and synaptically evoked currents by acting through a purinergic receptor with the pharmacology of the P2 type. ATP also induced a delayed slow outward current and depressed synaptic currents that appeared to result from hydrolysis of ATP to adenosine. The inhibitory actions had features suggesting mediation by a P1-like purinergic receptor. Suramin, a putative P2 antagonist, inhibited ATP-induced fast inward currents but did not suppress synaptic currents evoked by dorsal root stimulation. It was concluded that in the SG, ATP released in synaptic regions acts as a synaptic modulator by augmenting excitatory amino acid actions and possibly by also producing a secondary adenosine inhibition.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0270-6474
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3357-65
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
ATP modulation of synaptic transmission in the spinal substantia gelatinosa.
pubmed:affiliation
Department of Physiology, University of North Carolina at Chapel Hill 27599, USA.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, U.S. Gov't, P.H.S.