|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1995-6-22
|
|
pubmed:abstractText |
Antibody responses in recent human immunodeficiency virus (HIV) seroconverters to 2 vaccines were studied. Twenty patients infected with HIV for < 18 months and 15 HIV-seronegative controls were vaccinated with the 23-valent pure polysaccharide pneumococcal vaccine and the Haemophilus influenzae type b (Hib) capsular polysaccharide diphtheria CRM197 protein toxoid conjugate vaccine in separate arms. Despite increased levels of total serum IgG, recent seroconverters and controls showed similar specific IgG responses for 6 of 7 antigens. Baseline levels were equivalent in both groups, as were peak levels of IgG at 1 month to conjugated polysaccharide (Hib), delayed-type hypersensitivity, and pneumococcal capsular serotypes 4, 6B, 12F, and 14. At 6 months, IgG levels were similar for 4 of 7 antigens. Antibody responses to pure pneumococcal capsular polysaccharides and to a protein recall antigen were most often similar among recent seroconverters and seronegative controls. Both total levels and fold-rises of IgG to the Hib conjugate were similar in the 2 groups. Immunization of HIV-infected patients soon after seroconversion rather than later appears to improve antibody responses.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Diphtheria Toxoid,
http://linkedlifedata.com/resource/pubmed/chemical/Haemophilus Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/HibTITER protein, Haemophilus...,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Pneumococcal Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Conjugate
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0022-1899
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
171
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1217-22
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:7751696-Adult,
pubmed-meshheading:7751696-Antibodies, Bacterial,
pubmed-meshheading:7751696-Bacterial Proteins,
pubmed-meshheading:7751696-Bacterial Vaccines,
pubmed-meshheading:7751696-Case-Control Studies,
pubmed-meshheading:7751696-Cohort Studies,
pubmed-meshheading:7751696-Diphtheria Toxoid,
pubmed-meshheading:7751696-HIV Infections,
pubmed-meshheading:7751696-HIV Seropositivity,
pubmed-meshheading:7751696-Haemophilus Vaccines,
pubmed-meshheading:7751696-Humans,
pubmed-meshheading:7751696-Immunoglobulin G,
pubmed-meshheading:7751696-Matched-Pair Analysis,
pubmed-meshheading:7751696-Middle Aged,
pubmed-meshheading:7751696-Military Personnel,
pubmed-meshheading:7751696-Pneumococcal Vaccines,
pubmed-meshheading:7751696-Streptococcus pneumoniae,
pubmed-meshheading:7751696-United States,
pubmed-meshheading:7751696-Vaccination,
pubmed-meshheading:7751696-Vaccines, Conjugate
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
Response of recent human immunodeficiency virus seroconverters to the pneumococcal polysaccharide vaccine and Haemophilus influenzae type b conjugate vaccine.
|
|
pubmed:affiliation |
Department of Internal Medicine (Infectious Disease Division), Naval Medical Center, San Diego, California, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|
