| pubmed-article:7751644 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7751644 | lifeskim:mentions | umls-concept:C0597404 | lld:lifeskim |
| pubmed-article:7751644 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:7751644 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:7751644 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:7751644 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:7751644 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:7751644 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:7751644 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:7751644 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:7751644 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:7751644 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:7751644 | pubmed:dateCreated | 1995-6-22 | lld:pubmed |
| pubmed-article:7751644 | pubmed:abstractText | The dramatic increase in the cellularity of the mediastinal lymph nodes (MLN) of mice infected intranasally (i.n.) with influenza viruses is a consequence of both recruitment and proliferation. As many as 20% of the CD8+ subset in the MLN can be shown to be in S or G2 + M phase at 6 days after i.n. challenge with the HKx31 influenza A virus, the percentage of of cycling cells being approximately five times greater for the activated/memory substantial evidence of apoptosis was found for CD8+ T cells recovered from the MLN and lung, particularly at 5 and 7 days after infection. Less than 1/100 of the proliferating T cells could be shown, by limiting dilution analysis (LDA), to be influenza virus-specific CD8+ cytotoxic T lymphocyte precursors (CTLp). A single, low dose (20 mg/kg) of the DNA-targeted drug cyclophosphamide (Cy) caused a massive decrease in frequency for the responding CD8+ CTLp, though the mice survived infection with the HKx31 virus and there was no long-term exhaustion of the CTLp pool in the MLN, spleen, or lung. The Cy treatment was also followed by a smaller reduction in the prevalence of memory CTLp (specific for Sendai virus) that were present concurrently in the regional lymph node, indicating that a measure of bystander activation is occurring. The experiments show that respiratory virus infections have no negative impact on established T cell memory, and that there is no phase of transient exhaustion in the acute virus-specific CTLp response in this localized infection. | lld:pubmed |
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| pubmed-article:7751644 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7751644 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7751644 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7751644 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7751644 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7751644 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7751644 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7751644 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:7751644 | pubmed:author | pubmed-author:HoustonJJ | lld:pubmed |
| pubmed-article:7751644 | pubmed:author | pubmed-author:DohertyP CPC | lld:pubmed |
| pubmed-article:7751644 | pubmed:author | pubmed-author:HouSS | lld:pubmed |
| pubmed-article:7751644 | pubmed:author | pubmed-author:TrippR ARA | lld:pubmed |
| pubmed-article:7751644 | pubmed:author | pubmed-author:McMickleAA | lld:pubmed |
| pubmed-article:7751644 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7751644 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7751644 | pubmed:volume | 154 | lld:pubmed |
| pubmed-article:7751644 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7751644 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7751644 | pubmed:pagination | 6013-21 | lld:pubmed |
| pubmed-article:7751644 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7751644 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7751644 | pubmed:articleTitle | Recruitment and proliferation of CD8+ T cells in respiratory virus infections. | lld:pubmed |
| pubmed-article:7751644 | pubmed:affiliation | Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. | lld:pubmed |
| pubmed-article:7751644 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7751644 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7751644 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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