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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5 Pt 1
|
| pubmed:dateCreated |
1995-6-22
|
| pubmed:abstractText |
In this study we describe a series of nine patients affected by acquired immunodeficiency syndrome (AIDS) or AIDS-related complex who had hypereosinophilia and hyperimmunoglobulinemia E (hyper-IgE) with chronic dermatitis and recurrent staphylococcal infections. These patients had features similar to those present in hyper-IgE syndrome, a primary immunodeficiency disease. In addition, immunologic characterization of these patients with human immunodeficiency virus (HIV) infection, compared with 51 HIV-positive patients without hyper-IgE, both atopic and nonatopic, and three patients affected by the primary hyper-IgE syndrome, also revealed an increase in IgA and a severe decrease in B and CD4+ lymphocytes. Spontaneous in vitro synthesis of IgE by peripheral blood mononuclear cells was confirmed in both hyper-IgE conditions, together with increased levels of circulating eosinophil cationic protein. Serum-soluble CD23, usually increased in atopic conditions and hyper-IgE, was similar to that of normal control subjects in the HIV-positive patients with hyper-IgE. On the basis of our findings, we conclude that a hyper-IgE-like syndrome represents a distinct aspect of the clinical manifestations associated with HIV infection and that the immunologic mechanisms in this condition seem to differ from those known in primary hyper-IgE syndrome, because CD4+ TH2 type cells, which are currently believed to have a role in IgE production, are severely depleted in HIV-positive patients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Eosinophil Granule Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Isotypes,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleases
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0091-6749
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
95
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
995-1003
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7751521-AIDS-Related Complex,
pubmed-meshheading:7751521-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:7751521-Adult,
pubmed-meshheading:7751521-Antigens, CD,
pubmed-meshheading:7751521-Blood Proteins,
pubmed-meshheading:7751521-Eosinophil Granule Proteins,
pubmed-meshheading:7751521-Eosinophilia,
pubmed-meshheading:7751521-Female,
pubmed-meshheading:7751521-HIV Infections,
pubmed-meshheading:7751521-HLA-DR Antigens,
pubmed-meshheading:7751521-Humans,
pubmed-meshheading:7751521-Hypersensitivity, Immediate,
pubmed-meshheading:7751521-Immunoglobulin E,
pubmed-meshheading:7751521-Immunoglobulin Isotypes,
pubmed-meshheading:7751521-Job's Syndrome,
pubmed-meshheading:7751521-Lymphocyte Subsets,
pubmed-meshheading:7751521-Male,
pubmed-meshheading:7751521-Middle Aged,
pubmed-meshheading:7751521-Ribonucleases
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Immunologic aspects of hyperimmunoglobulinemia E-like syndrome in patients with AIDS.
|
| pubmed:affiliation |
Department of Allergy and Clinical Immunology, University La Sapienza, Rome, Italy.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|