Linked Life Data

7750653

Source:http://linkedlifedata.com/resource/pubmed/id/7750653

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-6-16
pubmed:abstractText
In the mouse, disruption of the endothelin-1 (ET-1) gene causes severe craniofacial deformities, including mandibular hypoplasia. Since the phenotype of ET-1-deficient mice shows features in common with inherited human mandibulofacial dysostosis, we investigated the presence of ET-1 and its receptors in human fetal craniofacial tissues of 9- to 12-week-old fetuses. We found that ET-1 is immunolocalized in the epithelial cells of the oral cavity. Radioligand binding studies indicate the presence of elevated concentrations of both ETA and ETB receptors in membranes derived from fetal jaws. Using autoradiography, 125I-ET-1 binding sites were shown to be localized within the embryonic mandibular process of the oral cavity, where they were confined to the mesenchymal-derived osteogenic cells. Our data suggest a role for ET-1 in the development of the human mandible.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0012-1606
pubmed:author
pubmed:issnType
Print
pubmed:volume
169
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
373-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Identification and localization of endothelin-1 and its receptors in human fetal jaws.
pubmed:affiliation
Department of Anatomy and Histology, University of Florence, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't