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pubmed-article:7750582pubmed:issue6lld:pubmed
pubmed-article:7750582pubmed:dateCreated1995-6-20lld:pubmed
pubmed-article:7750582pubmed:abstractTextTo determine the association between combined monophasic oral contraceptive (OC) use and primary infertility.lld:pubmed
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pubmed-article:7750582pubmed:issn0015-0282lld:pubmed
pubmed-article:7750582pubmed:authorpubmed-author:ThompsonS JSJlld:pubmed
pubmed-article:7750582pubmed:authorpubmed-author:CokerA LALlld:pubmed
pubmed-article:7750582pubmed:authorpubmed-author:AddyC LCLlld:pubmed
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pubmed-article:7750582pubmed:authorpubmed-author:BagwellM AMAlld:pubmed
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pubmed-article:7750582pubmed:volume63lld:pubmed
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pubmed-article:7750582pubmed:pagination1161-6lld:pubmed
pubmed-article:7750582pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:7750582pubmed:otherAbstractPIP: Researchers compared data on 419 nulligravid US women diagnosed with primary infertility (no conception during 24 consecutive months of unprotected intercourse) with data on 2120 fertile women to examine the relationship between use of combined monophasic oral contraceptives (OCs) and primary infertility. All cases had documented reproductive histories from menarche to menopause for contraceptive methods before infertility. Controls were more likely than infertile women to have used OCs (14.2% vs. 9.07%; unadjusted odds ratio [OR] = 0.6) and to have used OCs longer (33.6 vs. 30.1 months; OR = 0.6). Infertile women were just as likely as fertile women to have used high-estrogen-dose OCs (i.e., 50 mcg) (5.28% vs. 8.52%). Fertile women were more likely than infertile women to have used barrier methods (41.8% vs. 17.2%; OR = 0.29). When the researchers adjusted for education and barrier method use, infertile women were still less likely to have used OCs than fertile women, especially women who were 20 years old at first conception or infertility (adjusted OR [AOR] = 0.27) (AOR = 0.68 for older women). Both high- and low-estrogen-dose OCs were associated with a reduced risk of primary infertility (AOR = 0.48 for or= 50 mcg and 0.4 for 50 mcg). These results suggest that combined OC use reduces the risk of primary infertility, especially among younger women, regardless of duration of use or estrogen dose.lld:pubmed
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pubmed-article:7750582pubmed:year1995lld:pubmed
pubmed-article:7750582pubmed:articleTitlePrimary infertility and oral contraceptive steroid use.lld:pubmed
pubmed-article:7750582pubmed:affiliationRichland Memorial Hospital, Columbia, South Carolina, USA.lld:pubmed
pubmed-article:7750582pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:7750582pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed