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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1995-6-20
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pubmed:abstractText |
To determine the association between combined monophasic oral contraceptive (OC) use and primary infertility.
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pubmed:grant |
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pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Age Factors,
http://linkedlifedata.com/resource/pubmed/keyword/Americas,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Case Control Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Methods,
http://linkedlifedata.com/resource/pubmed/keyword/Demographic Factors,
http://linkedlifedata.com/resource/pubmed/keyword/Developed Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Estrogens,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Infertility,
http://linkedlifedata.com/resource/pubmed/keyword/North America,
http://linkedlifedata.com/resource/pubmed/keyword/Northern America,
http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives,
http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives, Combined,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Population,
http://linkedlifedata.com/resource/pubmed/keyword/Population Characteristics,
http://linkedlifedata.com/resource/pubmed/keyword/Population Dynamics,
http://linkedlifedata.com/resource/pubmed/keyword/Reproduction,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Research Report,
http://linkedlifedata.com/resource/pubmed/keyword/Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Time Factors,
http://linkedlifedata.com/resource/pubmed/keyword/United States
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0015-0282
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1161-6
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pubmed:dateRevised |
2007-11-14
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pubmed:otherAbstract |
PIP: Researchers compared data on 419 nulligravid US women diagnosed with primary infertility (no conception during 24 consecutive months of unprotected intercourse) with data on 2120 fertile women to examine the relationship between use of combined monophasic oral contraceptives (OCs) and primary infertility. All cases had documented reproductive histories from menarche to menopause for contraceptive methods before infertility. Controls were more likely than infertile women to have used OCs (14.2% vs. 9.07%; unadjusted odds ratio [OR] = 0.6) and to have used OCs longer (33.6 vs. 30.1 months; OR = 0.6). Infertile women were just as likely as fertile women to have used high-estrogen-dose OCs (i.e., 50 mcg) (5.28% vs. 8.52%). Fertile women were more likely than infertile women to have used barrier methods (41.8% vs. 17.2%; OR = 0.29). When the researchers adjusted for education and barrier method use, infertile women were still less likely to have used OCs than fertile women, especially women who were 20 years old at first conception or infertility (adjusted OR [AOR] = 0.27) (AOR = 0.68 for older women). Both high- and low-estrogen-dose OCs were associated with a reduced risk of primary infertility (AOR = 0.48 for or= 50 mcg and 0.4 for 50 mcg). These results suggest that combined OC use reduces the risk of primary infertility, especially among younger women, regardless of duration of use or estrogen dose.
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pubmed:meshHeading |
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pubmed:year |
1995
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pubmed:articleTitle |
Primary infertility and oral contraceptive steroid use.
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pubmed:affiliation |
Richland Memorial Hospital, Columbia, South Carolina, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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