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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1995-6-21
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pubmed:abstractText |
The induction of hepatic drug-metabolizing enzymes by chlornitrofen (CNP) and CNP-amino was studied in the liver of male rats and mice. CNP-amino increased the activities of 7-pentoxyresorufin O-depentylase (PROD) and 7-benzyloxyresorufin O-debenzylase (BROD) as CYP2B1-dependent monooxygenase 3.6- and 4.1-fold in rats. On the contrary, these enzyme activities in mice were induced by CNP rather than by CNP-amino. Furthermore, immunoblotting showed that the protein levels of CYP2B subfamily cytochrome P450 (P450) in liver microsomes of rats and mice were increased by CNP or CNP-amino. Phase II drug-metabolizing enzymes, UDP-glucuronyltransferase (UGT) and glutathione S-transferase (GST) levels in mice were also significantly increased from 1.4 to 2.5-fold by CNP or CNP-amino. However, neither CNP nor CNP-amino affected UGT and GST in rats. These results suggest that CNP and or CNP-amino induce the P450 isoforms of CYP2B subfamily in the rat and mouse liver, and that the inducibility of drug-metabolizing enzyme by the compounds is different between rats and mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,4,6-trichlorophenyl...,
http://linkedlifedata.com/resource/pubmed/chemical/2,4,6-trichlorophenyl-4'-aminophenyl...,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP2B1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronosyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/Herbicides,
http://linkedlifedata.com/resource/pubmed/chemical/Mutagens,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/Phenyl Ethers,
http://linkedlifedata.com/resource/pubmed/chemical/Water Pollutants, Chemical,
http://linkedlifedata.com/resource/pubmed/chemical/methoxyresorufin-O-demethylase
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0045-6535
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1297-309
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7749724-Animals,
pubmed-meshheading:7749724-Body Weight,
pubmed-meshheading:7749724-Cytochrome P-450 CYP1A1,
pubmed-meshheading:7749724-Cytochrome P-450 CYP2B1,
pubmed-meshheading:7749724-Cytochrome P-450 Enzyme System,
pubmed-meshheading:7749724-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:7749724-Enzyme Induction,
pubmed-meshheading:7749724-Glucuronosyltransferase,
pubmed-meshheading:7749724-Glutathione Transferase,
pubmed-meshheading:7749724-Herbicides,
pubmed-meshheading:7749724-Immunoblotting,
pubmed-meshheading:7749724-Liver,
pubmed-meshheading:7749724-Male,
pubmed-meshheading:7749724-Mice,
pubmed-meshheading:7749724-Microsomes, Liver,
pubmed-meshheading:7749724-Mutagens,
pubmed-meshheading:7749724-Organ Size,
pubmed-meshheading:7749724-Oxidoreductases,
pubmed-meshheading:7749724-Phenyl Ethers,
pubmed-meshheading:7749724-Rats,
pubmed-meshheading:7749724-Structure-Activity Relationship,
pubmed-meshheading:7749724-Water Pollutants, Chemical
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pubmed:year |
1995
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pubmed:articleTitle |
Induction of hepatic drug-metabolizing enzymes by chlornitrofen (CNP) and CNP-amino in rats and mice.
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pubmed:affiliation |
Division of Environmental Chemistry, National Institute of Health Sciences, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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