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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1995-6-12
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pubmed:abstractText |
The objects of this study were to investigate whether prostaglandin E2 (PGE2) can prevent orchidectomy (ORX)-induced cancellous bone loss in growing male rats, and to determine the differential effects of PGE2 on sham-operated (sham) and ORX male rats. Fourteen-week-old Sprague-Dawley male rats were divided into groups of basal, vehicle-treated sham, PGE2-treated sham, vehicle-treated ORX, and PGE2-treated ORX rats for either 3 or 9 weeks. PGE2 was given at 6 mg/kg body weight daily by subcutaneous injection. Static and dynamic cancellous bone histomorphometry were performed on double-fluorescent labeled undecalcified proximal tibial metaphyseal sections. No effect was observed by ORX on body weight or longitudinal bone growth rate when compared with sham-operated controls. However, androgen deficiency caused significant increases in percent eroded perimeter, mineral apposition rate, and bone turnover (bone-volume-referent-bone formation rate), which resulted in a significant decrease in trabecular bone number, increase in trabecular separation, and a nonsignificant decrease in trabecular bone area by 3 weeks of ORX. After 9 weeks of ORX, trabecular bone area and number were significantly decreased, and trabecular separation, percent eroded perimeter, and the index of bone turnover (bone-volume-referent-bone formation rate) remained significantly increased while the index of bone formation (tissue-volume-referent-bone formation rate) was nonsignificantly decreased when compared with sham controls. When 6 mg PGE2/kg/day was given for 3 and 9 weeks, similar anabolic effects were observed in sham and ORX rats.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0884-0431
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
66-73
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7747632-Aging,
pubmed-meshheading:7747632-Analysis of Variance,
pubmed-meshheading:7747632-Animals,
pubmed-meshheading:7747632-Body Weight,
pubmed-meshheading:7747632-Bone Density,
pubmed-meshheading:7747632-Bone Development,
pubmed-meshheading:7747632-Dinoprostone,
pubmed-meshheading:7747632-Image Processing, Computer-Assisted,
pubmed-meshheading:7747632-Injections, Subcutaneous,
pubmed-meshheading:7747632-Male,
pubmed-meshheading:7747632-Orchiectomy,
pubmed-meshheading:7747632-Osteoporosis,
pubmed-meshheading:7747632-Rats,
pubmed-meshheading:7747632-Rats, Sprague-Dawley,
pubmed-meshheading:7747632-Tibia
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pubmed:year |
1995
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pubmed:articleTitle |
Prostaglandin E2 administration prevents bone loss induced by orchidectomy in rats.
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pubmed:affiliation |
Division of Radiobiology, University of Utah School of Medicine, Salt Lake City 84112, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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