Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1995-6-12
|
| pubmed:abstractText |
The prevalence and distribution of lymphocyte subpopulations in normal and acanthotic ovine skin were investigated using monoclonal antibody immunocytochemistry. CD8+ cells were predominant in the epidermis of both normal and acanthotic skin, but were CD8+ cells, CD4+ cells and T19+ cells infrequent in normal epidermis. Within the dermis of normal skin, there were significantly greater numbers of CD4+ and T19+ cells situated around the superficial dermal vessels than in any other region examined. The majority of the CD8+ cells adjoined vessels, but the proportion that did not was greater for CD8+ than for CD4+ or T19+ cells. The CD4+ and CD8+ subsets were represented equally in adnexa. T cells were of memory phenotype. B cells and naive T cells, both of which express the CD45RA antigen, were rarely seen and tended to be associated with vessels in both normal and acanthotic skin. None of the T19+ cells (which are gamma delta+) resembled the dendritic gamma delta cells seen in murine epidermis. Acanthotic skin was strikingly different to normal skin. There was a greater abundance of T cells, particularly CD4+ cells, in acanthotic epidermis and the numbers of CD8+ and T19+ cells, and to a greater extent CD4+ cells, were greater at the dermal-epidermal junction. There were more CD4+ and CD8+ cells in the superficial dermal stroma of acanthotic skin. Within the dermis of acanthotic skin, T cells were concentrated near vessels but the apportioning of T cells between stromal/adnexal and vessel-associated sites differed from normal. Such observations suggest that migration away from perivascular sites and into the stroma may be controlled separately for subregions of skin and for each T cell subset. The role of this altered nonrandom migration of T cells in skin chronically exposed to ultra violet radiation is uncertain.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0165-2427
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
44
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
151-67
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1995
|
| pubmed:articleTitle |
The distribution of lymphocyte subpopulations in normal and acanthotic ovine skin.
|
| pubmed:affiliation |
Centre for Animal Biotechnology, University of Melbourne, Parkville, Vic., Australia.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|