Linked Life Data

7747306

Source:http://linkedlifedata.com/resource/pubmed/id/7747306

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-6-15
pubmed:abstractText
The detection of antibodies against keyhole limpet haemocyanin (KLH) (extracted from Megathura crenulata) has been described as a reliable tool for serological diagnosis of acute, but not chronic, schistosomiasis. We evaluated the immunoglobulin (Ig) G and IgM anti-KLH enzyme-linked immunosorbent assay (ELISA) for the serological diagnosis of light schistosome infections and to follow response after treatment, using sera from a group of Dutch travellers returning from Mali with acute schistosomiasis. Before chemotherapy, the sensitivities of the anti-KLH IgM and IgG ELISAs were 74% and 63%, respectively. In contrast, a sensitivity of 100% was found with an immunofluorescence assay for determination of IgM antibodies against gut-associated glycoconjugates. There was no significant difference in the anti-KLH response before, and one year after, therapy. These results indicate that, for travellers from non-endemic areas like The Netherlands with generally light schistosome infections, detection of antibody response against KLH is not a useful tool for serodiagnosis of acute schistosomiasis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0035-9203
pubmed:author
pubmed:issnType
Print
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
48-50
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Measurement of antibody response to keyhole limpet haemocyanin was not adequate for early diagnosis of schistosomiasis in a group of Dutch visitors to Mali.
pubmed:affiliation
Laboratory for Parasitology, Medical Faculty, University of Leiden, The Netherlands.
pubmed:publicationType
Journal Article