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rdf:type |
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lifeskim:mentions |
umls-concept:C0003009,
umls-concept:C0205548,
umls-concept:C0439851,
umls-concept:C0597357,
umls-concept:C0805732,
umls-concept:C1335960,
umls-concept:C1366753,
umls-concept:C1412113,
umls-concept:C1548425,
umls-concept:C1552596,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1947931,
umls-concept:C1948023
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pubmed:issue |
6528
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pubmed:dateCreated |
1995-6-14
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pubmed:abstractText |
The peptide angiotensin II is the effector molecule of the reninangiotensin system. All the haemodynamic effects of angiotensin II, including vasoconstriction and adrenal aldosterone release, are mediated through a single class of cell-surface receptors known as AT1 (refs 1, 2). These receptors contain the structural features of the G-protein-coupled receptor superfamily. We show here that angiotensin II induces the rapid phosphorylation of tyrosine in the intracellular kinases Jak2 and Tyk2 in rat aortic smooth-muscle cells and that this phosphorylation is associated with increased activity of Jak2. The Jak family substrates STAT1 and STAT2 (for signal transducers and activators of transcription) are rapidly tyrosine-phosphorylated in response to angiotensin II. We also find that Jak2 co-precipitates with the AT1 receptor, indicating that G-protein-coupled receptors may be able to signal through the intracellular phosphorylation pathways used by cytokine receptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/JAK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Jak2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Angiotensin,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/STAT2 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Stat1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
375
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
247-50
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7746328-Angiotensin II,
pubmed-meshheading:7746328-Animals,
pubmed-meshheading:7746328-Aorta,
pubmed-meshheading:7746328-Cell Line,
pubmed-meshheading:7746328-DNA-Binding Proteins,
pubmed-meshheading:7746328-Enzyme Activation,
pubmed-meshheading:7746328-Epidermal Growth Factor,
pubmed-meshheading:7746328-Humans,
pubmed-meshheading:7746328-Interferon-gamma,
pubmed-meshheading:7746328-Janus Kinase 2,
pubmed-meshheading:7746328-Muscle, Smooth, Vascular,
pubmed-meshheading:7746328-Phosphorylation,
pubmed-meshheading:7746328-Protein-Tyrosine Kinases,
pubmed-meshheading:7746328-Proto-Oncogene Proteins,
pubmed-meshheading:7746328-Rats,
pubmed-meshheading:7746328-Receptors, Angiotensin,
pubmed-meshheading:7746328-STAT1 Transcription Factor,
pubmed-meshheading:7746328-STAT2 Transcription Factor,
pubmed-meshheading:7746328-Trans-Activators,
pubmed-meshheading:7746328-Tyrosine
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pubmed:year |
1995
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pubmed:articleTitle |
Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor.
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pubmed:affiliation |
Department of Pathology, Emory University, Atlanta, Georgia 30322, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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