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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6528
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pubmed:dateCreated |
1995-6-14
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pubmed:abstractText |
Nuclear receptor heterodimers recognize response elements composed of two direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to five base pairs. The 1.9 A crystal structure of the complex formed by the DNA-binding domains of the 9-cis retinoic acid receptor and thyroid hormone receptor bound to a thyroid-response element shows that the subunits interact through a DNA-supported interface involving the carboxy-terminal extension of the DNA-binding domain of the thyroid hormone receptor. The stereochemistry suggests a mechanism by which heterodimers recognize the inter-half-site spacing between direct repeats.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
375
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
203-11
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7746322-Amino Acid Sequence,
pubmed-meshheading:7746322-Base Sequence,
pubmed-meshheading:7746322-Computer Graphics,
pubmed-meshheading:7746322-Crystallography, X-Ray,
pubmed-meshheading:7746322-DNA,
pubmed-meshheading:7746322-DNA-Binding Proteins,
pubmed-meshheading:7746322-Humans,
pubmed-meshheading:7746322-Models, Molecular,
pubmed-meshheading:7746322-Molecular Sequence Data,
pubmed-meshheading:7746322-Nucleic Acid Conformation,
pubmed-meshheading:7746322-Protein Conformation,
pubmed-meshheading:7746322-Protein Structure, Tertiary,
pubmed-meshheading:7746322-Receptors, Retinoic Acid,
pubmed-meshheading:7746322-Receptors, Thyroid Hormone,
pubmed-meshheading:7746322-Recombinant Fusion Proteins,
pubmed-meshheading:7746322-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:7746322-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:7746322-Sequence Homology, Amino Acid,
pubmed-meshheading:7746322-Structure-Activity Relationship
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pubmed:year |
1995
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pubmed:articleTitle |
Structural determinants of nuclear receptor assembly on DNA direct repeats.
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pubmed:affiliation |
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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