Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-6-15
pubmed:abstractText
The purpose of this study was to examine the possible association between "classic" motor neuron disease (cMND) and frontotemporal dementia (FTD), using neuropsychological evaluation and single photon emission computed tomography (SPECT). Psychological tests assessing language, perceptuospatial, memory, and "frontal lobe" functions were given to patients with cMND and test scores were compared with those of normal control subjects. 99mTc-HMPAO SPECT was performed on patients with cMND, FTD and motor neuron disease (FTD/MND), FTD alone, and normal control subjects. Regional cerebral blood flow indices (rCBFi) were determined in 36 cortical regions, and differences between grouped rCBFi data were investigated by canonical discriminant analysis. There were significant group differences in the scores of picture sequencing and token tests in patients with cMND compared with normal controls. Regional CBFi data showed frontal and anterior temporal reductions in patients with cMND compared with normal controls. A similar pattern of SPECT abnormality was seen in patients with FTD/MND and FTD alone, but to a more pronounced degree than in patients with cMND. Neuropsychological and SPECT findings in cMND, FTD/MND, and FTD showed a common pattern of cerebral involvement, most pronounced in the second two conditions. It is suggested that cMND, FTD/MND, and FTD represent a clinical range of a pathological continuum.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-1009768, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-1356048, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-1448236, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-1574993, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-1578230, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-16295108, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-1891084, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-2074448, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-2303828, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-2341906, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-2795200, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-3258902, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-3260610, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-3382182, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-3501273, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-3737834, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-3811831, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-4024859, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-5084341, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-7016254, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-7798998, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-8021663, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-8057109, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-8082664, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-8163988, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-8293278, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-8351013, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-8401781, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-8434885, http://linkedlifedata.com/resource/pubmed/commentcorrection/7745399-8460535
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-3050
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
541-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Inter-relation between "classic" motor neuron disease and frontotemporal dementia: neuropsychological and single photon emission computed tomography study.
pubmed:affiliation
Department of Neurology, Manchester Royal Infirmary, UK.
pubmed:publicationType
Journal Article