| pubmed-article:7744960 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7744960 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:7744960 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:7744960 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:7744960 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:7744960 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:7744960 | lifeskim:mentions | umls-concept:C0015350 | lld:lifeskim |
| pubmed-article:7744960 | lifeskim:mentions | umls-concept:C0929301 | lld:lifeskim |
| pubmed-article:7744960 | lifeskim:mentions | umls-concept:C0006141 | lld:lifeskim |
| pubmed-article:7744960 | lifeskim:mentions | umls-concept:C0040688 | lld:lifeskim |
| pubmed-article:7744960 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7744960 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:7744960 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:7744960 | lifeskim:mentions | umls-concept:C0078478 | lld:lifeskim |
| pubmed-article:7744960 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:7744960 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7744960 | pubmed:dateCreated | 1995-6-13 | lld:pubmed |
| pubmed-article:7744960 | pubmed:abstractText | Whey acidic protein (WAP) is an abundant rodent milk protein. Its expression in mouse mammary epithelial cell cultures was previously found to require the formation of an extracellular matrix (ECM)-induced three-dimensional alveolar structure. In the absence of such structures, cells were shown to secrete diffusible factors leading to suppression of WAP expression. We demonstrate here that (a) TGF-alpha production and secretion by mammary cells is downregulated by the basement membrane-dependent alveolar structure, and (b) compared with beta-casein, WAP expression is preferentially inhibited both in culture and in transgenic mice when TGF-alpha is added or overexpressed. Thus, (c) the enhanced TGF-alpha production when cells are not in three-dimensional structures largely accounts for the WAP-inhibitory activity found in the conditioned medium. Since this activity can be abolished by incubating the conditioned medium with a function blocking antibody to TGF-alpha. The data suggest that ECM upregulates WAP by downregulating TGF-alpha production. We also propose that changes in TGF-alpha activity during mouse gestation and lactation could contribute to the pattern of temporal expression of WAP in the gland. These results provide a clear example of cooperation among lactogenic hormones, ECM, and locally acting growth factors in regulation of tissue-specific gene expression. | lld:pubmed |
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| pubmed-article:7744960 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7744960 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7744960 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7744960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7744960 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7744960 | pubmed:month | May | lld:pubmed |
| pubmed-article:7744960 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:7744960 | pubmed:author | pubmed-author:BissellM JMJ | lld:pubmed |
| pubmed-article:7744960 | pubmed:author | pubmed-author:DempseyP JPJ | lld:pubmed |
| pubmed-article:7744960 | pubmed:author | pubmed-author:CoffeyR JRJ | lld:pubmed |
